Ammonium chloride |
| Katalog-Nr.GC63316 |
Ammoniumchlorid kann als heteropolare Verbindung mit pH-Wert-Regulierung eine intrazellulÄre Alkalisierung und metabolische Azidose verursachen, wodurch die enzymatische AktivitÄt beeinflusst und der Prozess des biologischen Systems beeinflusst wird. Ammoniumchlorid ist ein Autophagie-Hemmer.
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Cas No.: 12125-02-9
Sample solution is provided at 25 µL, 10mM.
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Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor[1][2].
Ammonium chloride (NH4Cl), a lysosomotropic agent that raises intralysosomal pH, reduces the yield of reovirus during infection of mouse L cells[2].
Ammonium chloride (0.28 M in drinking water) promotes the survival of myocardial cells in vivo by decreasing contractile dysfunction, cardiac hypertrophy, inflammation, apoptosis and autophagy[1].
[1]. Huang X, et al. NH4Cl treatment prevents doxorubicin-induced myocardial dysfunction in vivo. Life Sci. 2019;227:94-100. [2]. Canning WM, Fields BN. Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells. Science. 1983;219(4587):987-988.
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