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Arenavirus

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An arenavirus is a virus which is a member of the family Arenaviridae. These viruses infect rodents and occasionally humans.

Arenaviruses are a diverse family of small, enveloped, single-stranded RNA viruses which are generally propagated through asymptomatic, chronic infection of specific rodent hosts. Several arenaviruses are significant human pathogens, including five distinct hemorrhagic fever viruses designated category A by the CDC and NIAID, which is indicative of the level of highest threat to civilian populations. Several arenaviruses, including Lassa virus (LASV), are causative agents of hemorrhagic fever, for which effective therapeutic options are lacking.

The convergence of sensitivity to diverse small-molecule inhibitors thus identifies a robust new target for arenavirus antiviral discovery within the viral entry phase.

Products Related to Arenavirus(10)

  • GC28055 structure
    GC28055VV261
    CAS: 3003864-86-3
    Purity: >99.50%

    VV261 is an orally active prodrug of 4'-fluorouridine. VV261 inhibits viral RNA-dependent RNA polymerase.

  • GC18485 structure
    GC18485Retro-2
    CAS: 1429192-00-6
    Purity: >98.00%

    Retro-2 (RN 1-001) ist ein Dihydrochinazolinon (DHQZ)-Hemmer des retrograden Handels.

  • GC34252 structure
    GC34252GP(33-41)
    CAS: 161928-86-5
    Purity: >98%

    GP(33-41), ein 9 AminosÄuren langes Peptid, ist die optimale Sequenz des GP1-Epitops des lymphozytÄren Choriomeningitis-Virus und kann H-2Db-MolekÜle an der RMA-S (Db Kb)-ZelloberflÄche mit einem SC50 von hochregulieren 344 nM.

  • GC34375 structure
    GC34375ST-193 hydrochloride
    CAS: 2320274-72-2
    Purity: >98.50%

    ST-193-Hydrochlorid ist ein wirksamer Breitspektrum-Arenavirus-Hemmer; hemmt das Guanarito-, Junin-, Lassa- und Machupo-Virus mit IC50-Werten von 0,44, 0,62, 1,4 bzw. 3,1 nM.

  • GC37681 structure
    GC37681ST-193
    CAS: 489416-12-8
    Purity: >99.50%

    ST-193 ist ein potenter Breitband-Arenavirus-Hemmer; hemmt das Guanarito-, Junin-, Lassa- und Machupo-Virus mit IC50-Werten von 0,44, 0,62, 1,4 bzw. 3,1 nM.

  • GC37751 structure
    GC37751Tecovirimat
    CAS: 869572-92-9
    Purity: >98%
  • GC65001 structure
    GC65001LHF-535
    CAS: 1450929-77-7
    Purity: >99.00%

    LHF-535 ist ein antivirales Mittel, das aus dem Patent WO2013123215A2, Verbindung 38, extrahiert wurde und EC50-Werte von <1 μM, <1 μM, <1 μM und 1-10 μM f&Uuml;r Lassa-, Machupo-, Junin- bzw. VSVg-Virus aufweist .

  • GC65488 structure
    GC65488GP(33-41) TFA
    Purity: >99.50%

    GP(33-41) TFA, ein 9 Aminos&Auml;uren langes Peptid, ist die optimale Sequenz des GP1-Epitops des lymphozyt&Auml;ren Choriomeningitis-Virus.

  • GC69363 structure
    GC69363LCMV GP (61-80)
    CAS: 232598-19-5
    Purity: >98.00%

    LCMV GP (61-80) is a peptide fragment derived from the glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV), corresponding to amino acid sequence 61-80. LCMV GP (61-80) is a specific antigenic determinant cluster that can induce CD4+ T cell responses.

  • GN10629 structure
    GN106295,7-dihydroxychromone
    CAS: 31721-94-5
    Purity: >99.00%

    5,7-dihydroxychromone, a flavonoid decomposition product from peanut shells, inhibits the radicle elongation of velvetleaf, corn, peanut, and wheat.