Bifenthrin (Synonyms: (±)-Bifenthrin) |
Katalog-Nr.GC60642
One-Click Copy Product Info
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Bifenthrin ist ein synthetisches Pyrethroid-Insektizid, das die Öffnung von NatriumkanÄlen verlÄngert, was zu einer Membrandepolarisation und einer Leitungsblockierung im Nervensystem der Insekten fÜhrt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 82657-04-3
Sample solution is provided at 25 µL, 10mM.
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Bifenthrin is a pyrethroid insecticide whose principal target of the neurotoxic action is the neuronal membrane’s voltage-gated Na+ channel [1]. Bifenthrin has greater photostability and insecticidal activity, but is neurotoxic to various animals, and its clinical signs of toxicity including tremors and convulsions. [1, 2].
Bifenthrin (20μM; 24h) induced a marked increase in PGE2, NO and TNF-alpha production in primary microglia; Bifenthrin (20μM; 24h) increased the expression of IL-6 and TNF-alpha mRNA in primary microglia [3]. Bifenthrin (1, 1.5μM; 24h) significantly decreased glutathione peroxidase activity in erythrocytes; Bifenthrin (1.5μM; 24h) induced hemolysis in erythrocytes [2].
Bifenthrin (30, 60ng/L; 14d) increased the number of congested blood vessels of juvenile rainbow trout [4]. Bifenthrin (8mg/kg; 7d; i.p.) induced local nuclear pyknosis and vacuolar degeneration of liver tissues in some BALB/c mouse specimens; Bifenthrin (2, 4, 8mg/kg; 7d; i.p.) resulted in a concentration-dependent increase in mitochondrial ROS generation of BALB/c mice [5]. Bifenthrin (0.6mg/kg; 6weeks; qod.; i.g.) significantly increased body weight of C57BL/6 mice; Bifenthrin (0.6mg/kg; 6weeks; qod.; i.g.) significantly downregulated the expression of HSL and ATGL while significantly upregulated the expression of LPL of C57BL/6 mice [6].
References:
[1] Moreira C V L, Ogbu J s, Monteiro K L C, et al. Bifenthrin under scrutiny: revisiting toxicological evidence amid regulatory gaps [J]. Journal of applied toxicology : JAT, 2026, 46(1): 61-77.
[2] Mukhtar F, Jilani K, Bibi I, et al. Stimulation of erythrocyte membrane blebbing by Bifenthrin induced oxidative stress [J]. Dose-response : a publication of International Hormesis Society, 2022, 20(1): 15593258221076710.
[3] Gargouri B, Yousif N M, Bouchard M, et al. Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures [J]. Journal of neuroinflammation, 2018, 15(1): 159.
[4] Magnuson J T, Caceres L, Sy N, et al. The use of non-targeted lipidomics and histopathology to characterize the neurotoxicity of Bifenthrin to juvenile rainbow trout (Oncorhynchus mykiss) [J]. Environmental science & technology, 2022, 56(16): 11482-11492.
[5] Zhang Y, Lu M, Zhou P, et al. Multilevel evaluations of potential liver injury of bifenthrin [J]. Pesticide biochemistry and physiology, 2015, 122: 29-37.
[6] Wei C, Wang X, Yao X, et al. Bifenthrin induces fat deposition by improving fatty acid uptake and inhibiting lipolysis in mice [J]. Journal of agricultural and food chemistry, 2019, 67(51): 14048-14055.
| Cell experiment [1]: | |
Cell lines | Primary microglia of Sprague Dawley rats |
Preparation Method | Microglial cells were exposed to Bifenthrin (DMSO as a control) for 24h. Gene expression of TNF-alpha and IL-6 was analyzed by real-time quantitative PCR. |
Reaction Conditions | 20μM; 24h |
Applications | Bifenthrin increased the expression of IL-6 and TNF-alpha mRNA in primary microglia. |
| Animal experiment [2]: | |
Animal models | BALB/c mice |
Preparation Method | The animals were exposed daily to Bifenthrin via a 0.3 mL intraperitoneal injection of the appropriate concentration in corn oil. After a 7-day treatment period, the livers were collected for analysis. |
Dosage form | 2, 4, 8mg/kg; 7d; i.p. |
Applications | Bifenthrin resulted in a concentration-dependent increase in mitochondrial ROS generation. |
References: | |
| Cas No. | 82657-04-3 | SDF | |
| Überlieferungen | (±)-Bifenthrin | ||
| Canonical SMILES | O=C([C@H]1C(C)(C)[C@H]1/C=C(Cl)/C(F)(F)F)OCC2=C(C)C(C3=CC=CC=C3)=CC=C2 | ||
| Formula | C23H22ClF3O2 | M.Wt | 422.87 |
| Löslichkeit | DMSO: 100 mg/mL (236.48 mM) | Storage | 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3648 mL | 11.824 mL | 23.6479 mL |
| 5 mM | 473 μL | 2.3648 mL | 4.7296 mL |
| 10 mM | 236.5 μL | 1.1824 mL | 2.3648 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)