NPD-1335 |
| Katalog-Nr.GC36769 |
NPD1335 ist ein Trypanosoma brucei-Phosphodiesterase B1 (TbrPDEB1)-Inhibitor mit submikromolarer AktivitÄt gegen T.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2376326-31-5
Sample solution is provided at 25 µL, 10mM.
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NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. brucei parasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAMP levels and results in the distortion of the cell cycle and cell death[1]. pKi: 6.9 (TbrPDEB1); pIC50: 6.2 (T. brucei) (NPD-1335)[1]
[1]. de Heuvel E, et al. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2). Bioorg Med Chem. 2019 Jul 5. pii: S0968-0896(19)30790-4.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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