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Bilobalide

Katalog-Nr.GC12541 Copy One-Click Copy Product Info

A neuroprotective natural product

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Bilobalide Chemische Struktur

Cas No.: 33570-04-6

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10mM (in 1mL DMSO)
36,00 $
Auf Lager
25mg
35,00 $
Auf Lager
50mg
68,00 $
Auf Lager
100mg
124,00 $
Auf Lager

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Sample solution is provided at 25 µL, 10mM.



Description of Bilobalide

Description: IC50 Value: 3.33 (pIC50 Value) [1] Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba. An increasing number of studies have demonstrated its neuroprotective effects. in vitro: Inhibition by BB and GB was abolished in mutant receptors containing T6'S and S12'A substitutions, but their potencies were enhanced (42- and 125-fold, respectively) in S2'A mutant receptors [1]. BB enhanced the secretion of α-secretase-cleaved soluble amyloid precursor protein (sAPPα, a by-product of non-amyloidogenic processing of APP) and decreased the β amyloid protein (Aβ, a by-product of amyloidogenic processing of APP) via PI3K-dependent pathway [2]. in vivo: Oral administration of bilobalide (10-30 mg/kg) significantly inhibited thermal hyperalgesia in response to carrageenan, capsaicin and paw incision, independent of dose, with an efficacy similar to that of diclofenac. In the carrageenan model, mechanical hypersensitivity and paw oedema were also significantly reduced after treatment with bilobalide (10-30 mg/kg) [3]. BB(4 and 8 mg/kg) significantly protected VD rats against cognitive deficits in the Morris water maze. Biochemical assessment showed that BB (4 and 8 mg/kg) increased superoxide dismutase (SOD) activity and glutathione (GSH) content, and decreased nitric oxide synthase (NOS) activity and malondialdehyde (MDA) content [4]. Clinical trial: N/A

Chemical Properties of Bilobalide

Cas No. 33570-04-6 SDF
Canonical SMILES O=C1O[C@]([C@]([C@@](C2([H])[H])(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])O[H])([C@@]3([H])O[H])[C@](C4([H])[H])1[C@@]2([H])OC4=O)([H])OC3=O
Formula C15H18O8 M.Wt 326.3
Löslichkeit ≥ 16.3 mg/mL in DMSO, ≥ 98.2 mg/mL in EtOH with gentle warming Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Bilobalide

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.0647 mL 15.3233 mL 30.6466 mL
5 mM 612.9 μL 3.0647 mL 6.1293 mL
10 mM 306.5 μL 1.5323 mL 3.0647 mL
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In vivo Formulation Calculator (Clear solution) of Bilobalide

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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