BUR1 |
Katalog-Nr.GC72917
One-Click Copy Product Info
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BUR1 ist ein BMP-Upregulator (EC50: 98 nM) und aktiviert das BMPRII-Signal.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 23000-46-6
Sample solution is provided at 25 µL, 10mM.
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BUR1 is a BMP upregulator (EC50: 98 nM) and activates BMPRII signalling. BUR1 induces BMP2 and PTGS2 expression. BUR1 reversed pulmonary arterial pressure in Monocrotaline induced rats.
BUR1 (0.2 μM, 15 min-24 h) increases expression of Inhibitor of DNA binding 1 (Id1) and phosphorylation of Smad1/5 in PAECs[1].
BUR1 (4.5 mg/day, i.g., 3 weeks) reverses MCT-induced pulmonary arterial pressure and right ventricular systolic pressure in rats[1].
References:
[1]. Xing Y, et al. A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial pertension by regulating BMP2 and PTGS2 levels. Eur Respir J. 2018 Apr 4;51(4):1702229.
| Cas No. | 23000-46-6 | SDF | |
| Formula | C16H17N5 | M.Wt | 279.34 |
| Löslichkeit | Storage | -20°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.5799 mL | 17.8993 mL | 35.7987 mL |
| 5 mM | 716 μL | 3.5799 mL | 7.1597 mL |
| 10 mM | 358 μL | 1.7899 mL | 3.5799 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)