(+)-Cyclozonarone |
Katalog-Nr.GC78921
One-Click Copy Product Info
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(+)-Cyclozonarone is a benzoquinone derivative found in brown algae Dictyopteris undulata, with activity against T.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 332858-46-5
Sample solution is provided at 25 µL, 10mM.
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In Vitro, (+)-Cyclozonarone shows selective cytotoxicity toward MS-1 mouse endothelial cells with an IC50 of 0.1-0.5 μg/mL, and has IC50 values of 1-5 μg/mL for A-549 cells, 5 μg/mL for H-116 and PC-3 cells, and 1 μg/mL for HT-29 cells[1]. (+)-Cyclozonarone potently inhibits the growth of T. cruzi Tulahuen strain epimastigotes[1].
References:
[1]. Virginia Delgado, et al. Synthesis of racemic and chiral albicanol, albicanyl acetate and cyclozonarone: cytotoxic activity of ent-cyclozonarone. January 2008. Journal of the Brazilian Chemical Society. 19(7):1258-1263.
[2]. Wijeratne EM, et al. Sesquiterpene quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran Desert. J Nat Prod. 2008 Feb;71(2):218-22.
[3]. Rosales Martínez A, et al. Cp2TiCl-catalyzed, concise synthetic approach to marine natural product (±)-cyclozonarone. Synthetic Communications, 49(19), 2554-2560.
| Cas No. | 332858-46-5 | SDF | |
| Formula | C21H24O2 | M.Wt | 308.41 |
| Löslichkeit | Storage | Store at -20°C | |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.2424 mL | 16.2122 mL | 32.4244 mL |
| 5 mM | 648.5 μL | 3.2424 mL | 6.4849 mL |
| 10 mM | 324.2 μL | 1.6212 mL | 3.2424 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)