(+)-Cyclozonarone

(+)-Cyclozonarone is a benzoquinone derivative found in brown algae Dictyopteris undulata, with activity against T. cruzi epimastigotes, Tulahuen strains. (+)-Cyclozonarone inhibits growth of cancer and endothelial cells, and exhibits anti-leishmanial activity. (+)-Cyclozonarone can be used for the research of lung carcinoma, colon carcinoma, prostate carcinoma ^{[1] [2] [3]}.

In Vitro, (+)-Cyclozonarone shows selective cytotoxicity toward MS-1 mouse endothelial cells with an IC₅₀ of 0.1-0.5 μg/mL, and has IC₅₀ values of 1-5 μg/mL for A-549 cells, 5 μg/mL for H-116 and PC-3 cells, and 1 μg/mL for HT-29 cells^[1]. (+)-Cyclozonarone potently inhibits the growth of T. cruzi Tulahuen strain epimastigotes^[1].

References:
[1]. Virginia Delgado, et al. Synthesis of racemic and chiral albicanol, albicanyl acetate and cyclozonarone: cytotoxic activity of ent-cyclozonarone. January 2008. Journal of the Brazilian Chemical Society. 19(7):1258-1263.
[2]. Wijeratne EM, et al. Sesquiterpene quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran Desert. J Nat Prod. 2008 Feb;71(2):218-22.
[3]. Rosales Martínez A, et al. Cp2TiCl-catalyzed, concise synthetic approach to marine natural product (±)-cyclozonarone. Synthetic Communications, 49(19), 2554-2560.