Dimidium is a trypanocide.1,2 In vivo, dimidium (0.25-0.7 mg/kg) reduces parasite burden in T. congolense-infected mice.1 It also completely clears trypanosomes from the peripheral blood in zebu oxen naturally infected with T. congolense when administered intramuscularly at a dose of 0.75 mg/kg.2 Formulations containing dimidium have previously been used in the treatment of trypanosomiasis in cattle.
1.Woolfe, G.The trypanocidal action of phenanthridine compoundsAnn. Trop. Med. Parasitol.46(4)285-288(1952) 2.Wilde, J.K.H.Experimental use of dimidium bromide (1553) in the treatment of T. congolense infection in the zebu cattleJ. Comp. Pathol. Ther.59(1)48-53(1949)