DPP-4

Dipeptidyl peptidase-4 (DPP-4), originally identified in 1966 as a dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide, is a membrane-associated peptidase that selectively cleaves the N-terminal penultimate proline or alanine amino acids. The most common substrates of DPP-4 include glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), peptide YY, neuropeptide, chemokine ligand 12/stromal-derived factor-1 (CXCL12/SDF-1) and substance P. DPP-4, as a type II cell surface protein and a soluble form, has been found to be widely distributed in organs (such as the bone marrow, the lung, spleen, liver, pancreas, kidney and intestines) and body fluids (such as serum/plasma, cerebrospinal fluid, synovial fluid and semen). Besides its peptidase activity, DPP-4 has been found to be associated with immune stimulation, extracellular matrix degradation, lipid accumulation and resistance to anticancer agents.

Products Related to DPP-4(18)

GC12895 Saxagliptin
CAS: 361442-04-8
Purity: >99.50%
Saxagliptin (BMS-477118) ist ein potenter, selektiver, reversibler, kompetitiver und oral aktiver Inhibitor der Dipeptidylpeptidase-4 (DPP-4) (Ki = 0,6-1,3 nM).
GC10104 Glimepiride
CAS: 93479-97-1
Purity: >98.00%
Glimepiride is a second-generation sulfonylurea that stimulates pancreatic β cells to release insulin. Glimepiride is used for the treatment of type 2 diabetes mellitu as monotherapy as well as in combination with metformin or insulin.
GC10298 Sitagliptin phosphate monohydrate
CAS: 654671-77-9
Purity: >99.50%
GC10802 K 579
CAS: 440100-64-1
Purity: >98%
GC12235 Sitagliptin (phosphate)
CAS: 654671-78-0
Purity: >98.00%
Sitagliptin (Phosphat) (MK-0431-Phosphat) ist ein potenter Inhibitor von DPP4 mit einem IC50 von 19 nM in Caco-2-Zellextrakten.
GC12603 DPPI 1c hydrochloride
CAS: 866396-34-1
Purity: >98%
A DPP-4 inhibitor
GC13949 Alogliptin Benzoate
CAS: 850649-62-6
Purity: >99.50%
A DPP-4 inhibitor
GC14126 NVP DPP 728 dihydrochloride
CAS: 247016-69-9
Purity: >98%
GC14201 PK 44 phosphate
CAS: 1017682-65-3
Purity: >98%
DPP-IV inhibitor
GC14786 P32/98 (hemifumarate)
CAS: 251572-86-8
Purity: >98%
P32/98 (Hemifumarat) ist ein potenter Inhibitor der Dipeptidylpeptidase IV mit einem Ki-Wert von 130 nM.
GC14827 Linagliptin (BI-1356)
CAS: 668270-12-0
Purity: >99.50%
A potent DPP-4 inhibitor
GC15130 Alogliptin (SYR-322)
CAS: 850649-61-5
Purity: >99.00%
GC15576 Teneligliptin hydrobromide
CAS: 906093-29-6
Purity: >99.50%
A DPP-4 inhibitor
GC16613 Trelagliptin
CAS: 865759-25-7
Purity: >99.50%
A DDP-4 inhibitor
GC16733 Vildagliptin (LAF-237)
CAS: 274901-16-5
Purity: >98.00%
A DPP-4 inhibitor
GC17012 MK3102
CAS: 1226781-44-7
Purity: >99.00%
MK3102(Omarigliptin) ist ein neuartiger, einmal wöchentlich zu verabreichender Dipeptidylpeptidase-4(DPP-4)-Inhibitor(IC50-Wert: 2.2 nM), der zur Behandlung von Typ-2-Diabetes entwickelt wurde.
GC17479 Trelagliptin succinate
CAS: 1029877-94-8
Purity: >99.50%
A DDP-4 inhibitor
GC10018 Talabostat mesylate
CAS: 150080-09-4
Purity: >99.00%
Talabostat mesylate(PT100) ist ein oral wirksamer, nicht-selektiver Inhibitor der Dipeptidylpeptidase IV(DPP-IV)(IC 50 i = 0.18 nM) und der erste klinisch eingesetzte Inhibitor der Fibroblasten-Aktivierungsproteins(FAP)(IC 50 = 560 nM). Es hemmt auch DPP 8/9 (IC 50 = 4/11 nM; K i = 1.5/0.76 nM), Prolylendopeptidase(QPP) (IC50= 310 nM), DPP2 und weitere Enzyme der DASH-Familie.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC12895	Saxagliptin	361442-04-8	>99.50%
GC12895	Saxagliptin (BMS-477118) ist ein potenter, selektiver, reversibler, kompetitiver und oral aktiver Inhibitor der Dipeptidylpeptidase-4 (DPP-4) (Ki = 0,6-1,3 nM).
GC10104	Glimepiride	93479-97-1	>98.00%
GC10104	Glimepiride is a second-generation sulfonylurea that stimulates pancreatic β cells to release insulin. Glimepiride is used for the treatment of type 2 diabetes mellitu as monotherapy as well as in combination with metformin or insulin.
GC10298	Sitagliptin phosphate monohydrate	654671-77-9	>99.50%
GC10802	K 579	440100-64-1	>98%
GC12235	Sitagliptin (phosphate)	654671-78-0	>98.00%
GC12235	Sitagliptin (Phosphat) (MK-0431-Phosphat) ist ein potenter Inhibitor von DPP4 mit einem IC50 von 19 nM in Caco-2-Zellextrakten.
GC12603	DPPI 1c hydrochloride	866396-34-1	>98%
GC12603	A DPP-4 inhibitor
GC13949	Alogliptin Benzoate	850649-62-6	>99.50%
GC13949	A DPP-4 inhibitor
GC14126	NVP DPP 728 dihydrochloride	247016-69-9	>98%
GC14201	PK 44 phosphate	1017682-65-3	>98%
GC14201	DPP-IV inhibitor
GC14786	P32/98 (hemifumarate)	251572-86-8	>98%
GC14786	P32/98 (Hemifumarat) ist ein potenter Inhibitor der Dipeptidylpeptidase IV mit einem Ki-Wert von 130 nM.
GC14827	Linagliptin (BI-1356)	668270-12-0	>99.50%
GC14827	A potent DPP-4 inhibitor
GC15130	Alogliptin (SYR-322)	850649-61-5	>99.00%
GC15576	Teneligliptin hydrobromide	906093-29-6	>99.50%
GC15576	A DPP-4 inhibitor
GC16613	Trelagliptin	865759-25-7	>99.50%
GC16613	A DDP-4 inhibitor
GC16733	Vildagliptin (LAF-237)	274901-16-5	>98.00%
GC16733	A DPP-4 inhibitor
GC17012	MK3102	1226781-44-7	>99.00%
GC17012	MK3102(Omarigliptin) ist ein neuartiger, einmal wöchentlich zu verabreichender Dipeptidylpeptidase-4(DPP-4)-Inhibitor(IC50-Wert: 2.2 nM), der zur Behandlung von Typ-2-Diabetes entwickelt wurde.
GC17479	Trelagliptin succinate	1029877-94-8	>99.50%
GC17479	A DDP-4 inhibitor
GC10018	Talabostat mesylate	150080-09-4	>99.00%
GC10018	Talabostat mesylate(PT100) ist ein oral wirksamer, nicht-selektiver Inhibitor der Dipeptidylpeptidase IV(DPP-IV)(IC 50 i = 0.18 nM) und der erste klinisch eingesetzte Inhibitor der Fibroblasten-Aktivierungsproteins(FAP)(IC 50 = 560 nM). Es hemmt auch DPP 8/9 (IC 50 = 4/11 nM; K i = 1.5/0.76 nM), Prolylendopeptidase(QPP) (IC50= 310 nM), DPP2 und weitere Enzyme der DASH-Familie.