Eact |
Katalog-Nr.GC18142 |
Eact ist ein selektiver und potenter Aktivator von TMEM16A, aktiviert direkt die TRPV1-KanÄle in sensorischen Nozizeptoren und erzeugt Juckreiz, akute Nozizeption und thermische Überempfindlichkeit.
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Cas No.: 461000-66-8
Sample solution is provided at 25 µL, 10mM.
TMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator (EC50 = 3 μM). Also transient receptor potential vanilloid 1 (TRPV1) channel activator (EC50 = 11.6 μM). Ca2+-independent. Displays no effect on CFTR Cl- or ENaC Na+ conductance. Stimulates submucosal gland secretion in human bronchi.
Average Rating: 5
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