EcDsbB-IN-10 (compound 12) is an inhibitor of EcDsbB (E. coli DsbB) enzyme, with a Ki of 0.8 nM and an IC50 of 18.85 nM.
EcDsbB-IN-10 (compound 12) completely inhibits growth of the EcDsbB-dependent M. smegmatis strain at 400 nM, whereas the VKOR-dependent strain grew normally at concentrations up to and including 100 μM[1].
References:
[1]. Landeta C, et al. Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria. Nat Chem Biol. 2015 Apr;11(4):292-8.