EF24 |
| Katalog-Nr.GC64496 |
EF24 ist ein Curcumin-Analogon mit grÖßerer Anti-Tumor-Wirksamkeit und oraler BioverfÜgbarkeit durch Deaktivierung des MAPK/ERK-Signalwegs beim oralen Plattenepithelkarzinom (OSCC). Die Behandlung mit EF24 erhÖht die Spiegel der aktivierten Caspase 3 und 9 und verringert die phosphorylierten Formen von MEK1 und ERK.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 342808-40-6
Sample solution is provided at 25 µL, 10mM.
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EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK[1][2].
[1]. Lelli D, et al. Curcumin and treatment of melanoma: The potential role of microRNAs. Biomed Pharmacother. 2017 Apr;88:832-834. [2]. Mosley CA, et al. Highly active anticancer curcumin analogues. Adv Exp Med Biol. 2007;595:77-103.
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