EXP-7711 is a non peptide angiotensin II (Ang II) AT1 receptor antagonist. EXP-7711’s affinity for wild-type AT1 receptor ( K i =180 nM) is lower than peptide antagonists, but higher than losartan ( K i = 12 nM). EXP-7711 can be used for research on cardiovascular conditions [1].
References:
[1]. Noda K, et al. Tetrazole and carboxylate groups of angiotensin receptor antagonists bind to the same subsite by different mechanisms. J Biol Chem. 1995 Feb 3;270(5):2284-9.
References:
[1]. Noda K, et al. Tetrazole and carboxylate groups of angiotensin receptor antagonists bind to the same subsite by different mechanisms. J Biol Chem. 1995 Feb 3;270(5):2284-9.