Silvestrol aglycone |
| Katalog-Nr.GC37638 |
Silvestrol-Aglykon ist ein Silvestrol-Analogon, das die Initiation der Proteintranslation in Krebszellen mit EC50-Werten von 10 bzw. 200 nM fÜr myc-LUC- bzw. tub-LUC-Luciferase-Reporterprotein-Translation hemmt. Anti-Krebs-AktivitÄt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 960365-65-5
Sample solution is provided at 25 µL, 10mM.
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Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively. Anti-cancer activity[1].
Silvestrol aglycone (Compound 4) inhibits the proliferation of MDA-MB-231 cells with an E50 of 20 ± 10 nM after 72 h[1].
[1]. Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78.
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