Histone H4 peptide substrate (1-21) acetate is a PAD4 peptide substrate. Histone H4 peptide substrate (1-21) acetate serves as a substrate for the PAD4-catalyzed hydrolytic deimination of arginine residues, producing citrulline and ammonia [1].
In Vitro, Histone H4 peptide substrate (1-21) acetate (Compound H4-21) undergoes deimination catalyzed by purified recombinant human PAD4, exhibiting steady-state kinetic parameters comparable to those of benzoylated arginine derivatives[1].
References:
[1]. Kearney PL, et al. Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis. Biochemistry. 2005;44(31):10570-10582.
In Vitro, Histone H4 peptide substrate (1-21) acetate (Compound H4-21) undergoes deimination catalyzed by purified recombinant human PAD4, exhibiting steady-state kinetic parameters comparable to those of benzoylated arginine derivatives[1].
References:
[1]. Kearney PL, et al. Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis. Biochemistry. 2005;44(31):10570-10582.