JSD26 |
Katalog-Nr.GC79561
One-Click Copy Product Info
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JSD26 is a selective and orally active SCoR2 (AKR1A1) inhibitor with an IC50 of 93 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2353515-08-7
Sample solution is provided at 25 µL, 10mM.
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In Vivo, JSD26 (20-120 mg/kg, i.p., once) inhibits SCoR2 in mice without affecting AKR1B1[1]. JSD26 (120 mg/kg, i.p., once) alleviates symptoms in acute kidney injury (AKI) mice by selectively inhibiting SCoR2 and increasing S-nitrosylation of PKM2[1].
References:
[1]. Zhou HL, et al. Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney Injury. J Med Chem. 2023 Apr 27;66(8):5657-5668.
| Cas No. | 2353515-08-7 | SDF | |
| Formula | C18H14N2O2 | M.Wt | 290.32 |
| Löslichkeit | DMSO: 100 mg/mL (344.45 mM; Need ultrasonic) | Storage | Store at 4°C, sealed storage, away from moisture |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.4445 mL | 17.2224 mL | 34.4448 mL |
| 5 mM | 688.9 μL | 3.4445 mL | 6.889 mL |
| 10 mM | 344.4 μL | 1.7222 mL | 3.4445 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)