JT71 is an inhibitor of the transcriptional activator MrkH of type III fimbriae in Klebsiella pneumoniae. JT71 reduces the activity of the mrkA promoter in Klebsiella pneumoniae, effectively inhibiting the formation of biofilms by Klebsiella pneumoniae, while not affecting the cell's viability. JT71 can be used for research on Klebsiella pneumoniae infections [1].
References:
[1]. Wilksch JJ, et al. Chemical inhibition of MrkH-dependent activation of type 3 fimbriae synthesis and biofilm formation by Klebsiella pneumoniae. NPJ Biofilms Microbiomes. 2025 Nov 20;11(1):212.
References:
[1]. Wilksch JJ, et al. Chemical inhibition of MrkH-dependent activation of type 3 fimbriae synthesis and biofilm formation by Klebsiella pneumoniae. NPJ Biofilms Microbiomes. 2025 Nov 20;11(1):212.