L-Threonine-d2 is intended for use as an internal standard for the quantification of L-threonine by GC- or LC-MS. L-Threonine is an essential amino acid.1 It undergoes catabolism via threonine dehydrogenase to yield the glucogenic metabolites succinyl coenzyme A (succinyl CoA) and pyruvate. Administration of L-threonine-deficient diets induces lameness of the thoracic and pelvic limbs and decreases food intake and weight gain in kittens.2
1.Massey, K.A., Blakeslee, C.H., and Pitkow, H.S.A review of physiological and metabolic effects of essential amino acidsAmino Acids14(4)271-300(1998) 2.Titchenal, C.A., Rogers, Q.R., Indrieri, R.J., et al.Threonine imbalance, deficiency and neurologic dysfunction in the kittenJ. Nutr.110(12)2444-2459(1980)