Lavendamycin is a bacterial metabolite that has been found in S. lavendulae and has antimicrobial and anticancer activities.1,2 It is active against various bacteria, including S. pneumoniae, S. aureus, E. coli, P. mirabilis, and P. vulgaris (MICs = 0.13-1 ?g/ml), and various fungi, including T. rubrum, T. mentagrophytes, and M. canis (MICs = 0.5 ?g/ml for all).1 Lavendamycin is cytotoxic to P388 murine leukemia, MKN45 gastric carcinoma, and WiDr colon adenocarcinoma cells (IC50s = 0.06, 0.1, 0.09 ?g/ml, respectively).2 In vivo, lavendamycin (0.4-6.4 mg/kg) increases median survival time in a P388 murine leukemia model.1
References:
[1]. Balitz, D.M., Bush, J.A., Bradner, W.T., et al.Isolation of lavendamycin, a new antibiotic from Streptomyces lavendulaeJ. Antibiot. (Tokyo)35(3)259-265(1982).
[2]. Abe, N., Nakakita, Y., Nakamura, T., et al.Novel cytocidal compounds, oxopropalines from Streptomyces sp. G324 producing lavendamycin. I. Taxonomy of the producing organism, fermentation, isolation and biological activitiesJ. Antibiot. (Tokyo)46(11)1672-1677(1993).