LCS3 |
Katalog-Nr.GC49753
One-Click Copy Product Info
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LCS3 ist ein reversibler und nicht kompetitiver Inhibitor der Glutathiondisulfidreduktase (GSR) und der Thioredoxinreduktase 1 (TXNRD1) (IC50=3,3 μM bzw. 3,8 μM). LCS3 zeigt AntitumoraktivitÄt und induziert Apoptose. LCS3 kann in der Forschung zum Lungenadenokarzinom (LUAD) eingesetzt werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 109844-92-0
Sample solution is provided at 25 µL, 10mM.
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LCS3 is an inhibitor of glutathione reductase (GR) and thioredoxin reductase (TrxR; IC50s = 3.3 and 3.8 µM, respectively).1 It decreases the glutathione (GSH) to oxidized GSH (GSSG) ratio in NCI H1650 and H23 lung adenocarcinoma cells in a concentration-dependent manner. LCS3 (3 µM) induces apoptosis in NCI H1650 and H23 cells but not non-transformed HPL1D lung epithelial cells. It is also active against M. tuberculosis (MIC = 0.098 µM).2
1.Johnson, F.D., Ferrarone, J., Liu, A., et al.Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cellsCell Rep.38(6)110343(2022) 2.Gallardo-Marcias, R., Kumar, P., Jaskowski, M., et al.Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agentBioorg. Med. Chem. Lett.29(4)601-606(2019)
| Cas No. | 109844-92-0 | SDF | |
| Canonical SMILES | O=C(NC1=CC=C(Cl)C=C1)C=2OC(=CC2)N(=O)=O | ||
| Formula | C11H7ClN2O4 | M.Wt | 266.6 |
| Löslichkeit | DMF: slightly,DMSO: 1 mg/ml,Ethanol: insol,PBS (pH 7.2): insol | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.7509 mL | 18.7547 mL | 37.5094 mL |
| 5 mM | 750.2 μL | 3.7509 mL | 7.5019 mL |
| 10 mM | 375.1 μL | 1.8755 mL | 3.7509 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A crystalline solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)