MCP110 |
| Katalog-Nr.GC61032 |
MCP110 ist ein Inhibitor der Ras/Raf-1-Interaktion. MCP110 blockiert die Interaktion von Ras mit Raf. MCP110 unterbricht diese Wechselwirkung und kÖnnte fÜr die Erforschung menschlicher Tumore eingesetzt werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 521310-51-0
Sample solution is provided at 25 µL, 10mM.
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MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf. MCP110 disrupts this interaction might can be used for the research of human tumors[1].
MCP110 (10 and 20 uM) inhibits H-Ras (V12)-induced AP-1 activation in HEK293 cells. Ras stimulation of Raf-1 activity is significantly decreased by MCP110 (20 μM) [1].MCP110 (1, 2, 5, 10, and 20 μM) shows a dose-dependent inhibition of elevated Raf-1 activity in fibrosarcoma HT1080 cells[1].MCP110 (20 μM) decreases cyclin D level stimulated by the treatment with EGF (100 ng/mL), platelet-derived growth factor (20 ng/mL) , serum, or phorbol 12-myristate 13-acetate (100 nM) in A549 cells[1].
[1]. Juran Kato-Stankiewicz,et al. Inhibitors of Ras/Raf-1 Interaction Identified by Two-Hybrid Screening Revert Ras-dependent Transformation Phenotypes in Human Cancer Cells. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14398-403.
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