MSU-43557 |
Katalog-Nr.GC78828
One-Click Copy Product Info
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MSU-43557 is a Mycobacterium abscessus MmpL3 ( MAB_4508 ) inhibitor and bactericidal agent.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2919699-59-3
Sample solution is provided at 25 µL, 10mM.
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In Vitro, MSU-43557 (80 μM-0.08 nM; 3 d) potently inhibits the growth of Mycobacterium abscessus ATCC 19977 in vitro, and exhibits time-dependent bactericidal activity at a concentration of 5× MIC; meanwhile, MSU-43557 potently inhibits strains of Mycobacterium tuberculosis, Mycobacterium abscessus and Mycobacterium smegmatis, shows no activity against non-mycobacterial species within 80 μM, and displays variable inhibitory activity against clinically isolated multidrug-resistant Mycobacterium abscessus strains[1]. MSU-43557 (0.18 nM-160 μM; 3 d) disrupts mature Mycobacterium abscessus biofilms with an EC50 of 8.66 μM; it also reduces bacterial viability within biofilms, with a corresponding EC50 of 0.16 μM[1]. MSU-43557 (0.18 nM-160 μM; 3 d) kills intracellular Mycobacterium abscessus ATCC 19977 in mouse bone marrow-derived macrophages with an EC50 of 0.39 μM, and exhibits low cytotoxicity toward mouse bone marrow-derived macrophages[1].
References:
[1]. Abdalla BJ, et al. Defining the Mechanism of Action and Resistance of New Mycobacterium abscessus MmpL3 Inhibitors. ACS Chem Biol. 2026 Feb 20;21(2):284-301.
| Cas No. | 2919699-59-3 | SDF | |
| Formula | C15H17Cl2N3O | M.Wt | 326.22 |
| Löslichkeit | DMSO: 100 mg/mL (306.54 mM; Need ultrasonic) | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.0654 mL | 15.3271 mL | 30.6542 mL |
| 5 mM | 613.1 μL | 3.0654 mL | 6.1308 mL |
| 10 mM | 306.5 μL | 1.5327 mL | 3.0654 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)