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Norgestimate-d6 (Synonyms: Dexnorgestrel acetime-d6)

Katalog-Nr.GC47797 Copy One-Click Copy Product Info

An internal standard for the quantification of norgestimate

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Norgestimate-d6 Chemische Struktur

Cas No.: 1263194-12-2

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500 μg
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1 mg
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Sample solution is provided at 25 µL, 10mM.



Description of Norgestimate-d6

Norgestimate-d6 is intended for use as an internal standard for the quantification of norgestimate by GC- or LC-MS. Norgestimate is a progestin and a prodrug form of norelgestromin and levonorgestrel .1,2 It binds to progestin receptors (mean IC50 = 3.48 nM for rabbit uterine receptors) and is selective for progestin over androgen receptors (mean IC50 = 764 nM for rat prostatic receptors) in radioligand binding assays.3 Norgestimate maintains pregnancy in ovariectomized female rats in a dose-dependent manner.1 It inhibits ovulation in 100% of female rats when administered at a dose of 0.5 mg/kg. Norgestimate (2 mg/kg) completely inhibits estrone-induced vaginal cornification in ovariectomized female rats, indicating antiestrogenic activity. Formulations containing norgestimate in combination with ethinyl estradiol have been used as oral contraceptives and in the treatment of acne vulgaris.

1.Hahn, D.W., Allen, G.O., and McGuire, J.L.The pharmacological profile of norgestimate, a new orally active progestinContraception16(5)541-553(1977) 2.Stanczyk, F.Z.All progestins are not created equalSteroids68(10-13)879-890(2003) 3.Phillips, A., Demarest, K., Hahn, D.W., et al.Progestational and androgenic receptor binding affinities and in vivo activities of norgestimate and other progestinsContraception41(4)399-410(1990)

Chemical Properties of Norgestimate-d6

Cas No. 1263194-12-2 SDF
Überlieferungen Dexnorgestrel acetime-d6
Canonical SMILES CC[C@@]12[C@](CC[C@@]2(OC(C)=O)C#C)([H])[C@]3([H])CC([2H])([2H])C4=C([2H])/C(C([2H])([2H])C[C@]4([2H])[C@@]3([H])CC1)=N/O
Formula C23H25D6NO3 M.Wt 375.5
Löslichkeit Methanol: soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Norgestimate-d6

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.6631 mL 13.3156 mL 26.6312 mL
5 mM 532.6 μL 2.6631 mL 5.3262 mL
10 mM 266.3 μL 1.3316 mL 2.6631 mL
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In vivo Formulation Calculator (Clear solution) of Norgestimate-d6

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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