Nucleic Acid Turnover/Signaling

Akt1, 2, and 3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.

8-Nitroguanine is a nitrative guanine derivative formed by oxidative damage to the guanine base in DNA by reactive nitrogen species (RNS) during inflammation and in vitro by reaction of DNA with peroxynitrite and other RNS reagents.

DB2115 (Tertahydrochlorid) ist ein potenter Inhibitor des myeloiden Hauptregulators PU.1. DB2115 (Tertahydrochlorid) hat das Potenzial fÜr die Erforschung von Krebs, einschließlich hÄmatologischer Krebsarten wie LeukÄmie, sowie anderer Erkrankungen, die mit Dekubitus assoziiert sind. 1 Dysfunktion (aus Patent WO2017223260A1, Verbindung DB2115) .

β-Amanitin ist ein zyklisches Peptid-Toxin im giftigen Pilz Amanita phalloides. β-Amanitin hemmt hemmt die eukaryotische RNA-Polymerase II und III. β-Amanitin hemmt die Proteinsynthese. β-Amanitin kann als zytotoxischer Bestandteil von AntikÖrper-Wirkstoff-Konjugaten (ADCs) verwendet werden.

Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S.

Ciprofloxacin-d8 is intended for use as an internal standard for the quantification of ciprofloxacin by GC- or LC-MS.

Tigecycline-d9 is intended for use as an internal standard for the quantification of tigecycline by GC- or LC-MS.

Dihydroresveratrol is a major metabolite of resveratrol that is produced by animal-associated bacteria, including the gut microbiota.

6-Aminophenanthridin hemmt die ProteinfaltungsaktivitÄt des Ribosoms (PFAR).

(R)-Gyramide A (Hydrochlorid) ist ein bakterieller DNA-Gyrase-Inhibitor, der die Supercoiling-Aktivität mit einem IC50-Wert von 3,3 µM stört.

5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS.

Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.

9-Deazaguanine is a purine nucleoside analog with oral activity, functioning as a potent inhibitor of purine nucleoside phosphorylase (PNP).

Ametantron (NSC 196473) ist ein Antitumormittel, das in DNA interkaliert und einen durch Topoisomerase II (TOP2) vermittelten DNA-Bruch induziert.

Pemetrexed (Natriumsalzhydrat) ist ein neuartiges Antifolat, die Ki-Werte des Pentaglutamats von LY231514 betragen 1,3, 7,2 und 65 nM fÜr die Hemmung der Thymidylatsynthase (TS), der Dihydrofolatreduktase (DHFR) bzw. der Glycinamid-Ribonukleotid-Formyltransferase (GARFT). .

Trimethoprim is an antibiotic that inhibits dihydrofolate reductase (DHFR) and shows selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively).

An internal standard for quantifying doxycycline

An internal standard for the quantification of docosanoic acid

A neuropeptide with diverse biological activities

A neuropeptide with diverse biological activities

A protein synthesis inhibitor with diverse biological activities

A cGAS inhibitor

A cGAS inhibitor

A neuropeptide with diverse biological activities