MST-312 (Synonyms: Telomerase Inhibitor IX) |
| Katalog-Nr.GC18769 |
DB2115 (Tertahydrochlorid) ist ein potenter Inhibitor des myeloiden Hauptregulators PU.1. DB2115 (Tertahydrochlorid) hat das Potenzial fÜr die Erforschung von Krebs, einschließlich hÄmatologischer Krebsarten wie LeukÄmie, sowie anderer Erkrankungen, die mit Dekubitus assoziiert sind. 1 Dysfunktion (aus Patent WO2017223260A1, Verbindung DB2115) .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 368449-04-1
Sample solution is provided at 25 µL, 10mM.
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MST312 is a telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay). It is selective for telomerase over DNA polymerase when used at concentrations up to 3 μM. MST312 inhibits growth of U937 cells via telomere shortening (GI50 = 1.7 μM). It reduces cell number and expression of the proliferation marker MIB-1 as well as increases DNA damage in primary pediatric ependymoma tumor cells. MST312 decreases survival of H460 and H1299 non-small cell lung cancer (NSCLC) cells in a dose-dependent manner with a greater effect on the aldehyde dehydrogenase positive (ALDH+) cancer stem cell population. In vivo, MST312 (40 mg/kg) reduces tumor size by 70% in an H460 mouse xenograft model. MST312 also inhibits replication of herpes simplex virus 2 (HSV-2) and a clinical isolate of HSV-1 and decreases accumulation of early and late viral proteins in HEp-2 cells infected with HSV-1.
Review for MST-312
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
Review for MST-312
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