PKG Substrate |
Katalog-Nr.GC34227 |
PKG-Substrat ist ein selektives Substrat fÜr cGMP-abhÄngige Proteinkinase (PKG).
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Sample solution is provided at 25 µL, 10mM.
PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG).
Incorporation of [33P]ATP into the synthetic peptide PKG substrate RKRSRAE is measured. N6-benzyl-ATP inhibits kinase activity of PKG Iα gatekeeper mutants but not WT. The serotonin transporter (SERT) is responsible for reuptake of serotonin (5-hydroxytryptamine) after its exocytotic release from neurons. SERT is regulated by several processes, including a cyclic GMP signaling pathway involving nitric oxide synthase, guanylyl cyclase, and PKG[1].
[1]. Wong A, et al. Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase. J Biol Chem. 2012 Oct 19;287(43):36051-8.
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