Sp-8-bromo-Cyclic AMPS (sodium salt) (Synonyms: 8Bromoadenosine 3',5'cyclic Monophosphothioate SPIsomer, Sp8bromocAMPS) |
| Katalog-Nr.GC44920 |
Sp-8-bromo-cyclic AMPS (Sp-8-bromo-cAMPS) is a cell-permeable, cAMP analog that combines an exocyclic sulfur substitution in the axial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.
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Cas No.: 1573115-90-8
Sample solution is provided at 25 µL, 10mM.
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Sp-8-bromo-cyclic AMPS (Sp-8-bromo-cAMPS) is a cell-permeable, cAMP analog that combines an exocyclic sulfur substitution in the axial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. This configuration pools the structural features of two established cyclic-AMP-dependent protein kinase (PKA) activators, 8-bromo-cAMP and Sp-cAMPS . Sp-8-bromo-cAMPS is a PKA agonist (EC50 = 1.5 µM) with improved lipophilicity and is not readily degraded by cyclic nucleotide phosphodiesterases.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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