GLPBio

Proteasome

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The proteasome is a large multisubunit complex of approximately 2.5 MDa that mediates a wide range of physiological and pathological cellular processes by selectively degrading unnecessary proteins in eukaryotes. The structure of a proteasome is comprised of the catalytic core particle (CP) and two terminal regulatory particles (RPs). The CP (also known as the 20S proteasome) is a barrel shaped multisubunit complex (approximately 750 kDa) consisting of four axially stacked heptameric rings (two outer α-rings and two inner β-rings) with 7 subunits in each ring, where three β subunits (β1, β2 and β5) contain catalytically active threonine residues and are associated with caspase-like, trypsin-like and chymotrypsin-like activities respectively.

Products Related to Proteasome(77)

  • GC12003 structure
    GC12003VR23
    CAS: 1624602-30-7
    Purity: >99.00%

    VR23 ist ein kleines MolekÜl, das die AktivitÄten von Trypsin-Ähnlichen Proteasomen (IC50=1 nM), Chymotrypsin-Ähnlichen Proteasomen (IC50=50-100 nM) und Caspase-Ähnlichen Proteasomen (IC50=3 μM) wirksam hemmt.

  • GC15802 structure
    GC15802PI-1840
    CAS: 1401223-22-0
    Purity: >99.00%

    PI-1840 ist ein potenter und selektiver Chymotrypsin-Ähnlicher (CT-L) Inhibitor mit einem IC50-Wert von 27 nM. PI-1840 hemmt die Zellproliferation und hÄlt den Zellzyklus in der G2/M-Phase an. PI-1840 induziert Apoptose und induziert Autophagie. PI-1840 induziert die Akkumulation der Proteasom-Substrate p27, Bax und IκB-α.

  • GA20483 structure
    GA20483Ac-Arg-Leu-Arg-AMC
    CAS: 929903-87-7
    Purity: >98%

    Ac-Arg-Leu-Arg-AMC is a fluorescent peptide substrate (excitation/emission wavelength=380/440-460nm) used to detect the trypsin-like activity of the 26S proteasome.

  • GC10102 structure
    GC10102Aclacinomycin A
    CAS: 57576-44-0
    Purity: ≥95%

    An anthracycline with antibiotic and anticancer activities

  • GC10178 structure
    GC10178MG-115
    CAS: 133407-86-0
    Purity: >98.00%

    MG-115 ist ein potenter Inhibitor mit Ki-Werten von 21 nM bzw. 35 nM für das 20S- bzw. 26S-Proteasom.

  • GC10342 structure
    GC10342Calpeptin
    CAS: 117591-20-5
    Purity: >98.00%

    Calpeptin is a reversible and cell-permeable cysteine cathepsin inhibitor. The ID 50 values of Calpeptin for calpain I and II (porcine), papain, and platelet calpain I are 52nM, 34nM, 138nM, and 20nM, respectively. Calpeptin alleviates apoptosis and secondary inflammatory changes in muscle cells.

  • GC10383 structure
    GC10383MG-132
    CAS: 133407-82-6
    Purity: >98.00%

    MG-132 ist ein potenter Proteasom- und Calpain-Inhibitor mit IC 50 -Werten von 100 nM bzw. 1,25 μM.

  • GC10486 structure
    GC10486Salinosporamide A (NPI-0052, Marizomib)
    CAS: 437742-34-2
    Purity: >98.00%

    Salinosporamide A (NPI-0052, Marizomib) is a 20S proteasome inhibitor isolated from the obligate marine actinobacterium Salinispora tropica , exhibiting potent antitumor activity with an IC 50 value of 1.3nM.

  • GC10561 structure
    GC10561PD 151746
    CAS: 179461-52-0
    Purity: >98%

    PD151746 ist ein Calpain-Inhibitor, zeigt eine 20-fache SelektivitÄt fÜr u-Calpain (Ki = 0,26 ± 0,03 μM) gegenÜber m-Calpain (Ki = 5,33 ± 0,77 μM).

  • GC11640 structure
    GC11640MDL 28170
    CAS: 88191-84-8
    Purity: >97.00%

    MDL 28170, a cell permeable, reversible, peptidic aldehyde inhibitor of calpain (K i = 0.01μM; K i for cathepsin B = 0.025μM).

  • GC11974 structure
    GC11974Pepstatin A
    CAS: 26305-03-3
    Purity: >98.50%

    Pepstatin A ist ein oral wirksamer Inhibitor von Aspartatproteasen, der von Aktinomyzeten produziert wird.

  • GC12272 structure
    GC12272CEP-18770
    CAS: 847499-27-8
    Purity: >98.00%

    An inhibitor of chymotrypsin-like proteasome activity

  • GC12494 structure
    GC12494Epoxomicin
    CAS: 134381-21-8
    Purity: >98.50%

    Epoxomicin ist ein selektiver Proteasom-Inhibitor. Es hemmt effektiv die Chymotrypsin-ähnliche(CH-L) Aktivität des 20S-Proteasoms. Der IC 50 -Wert ist etwa 40-80 nM.

  • GC12527 structure
    GC12527MG-101 (Calpain Inhibitor I, ALLN)
    CAS: 110044-82-1
    Purity: >98.00%

    MG-101 (Calpain Inhibitor I, ALLN) also known as Calpain Inhibitor I, selectively inhibits various cysteine proteases, including calpain I, calpain II, cathepsin B, and cathepsin L. The corresponding Ki values for these enzymes are 90pM, 220pM, 150pM, and 500pM.

  • GC12784 structure
    GC12784Artemether (SM-224)
    CAS: 71963-77-4
    Purity: >98.00%

    An antiparasitic compound

  • GC13123 structure
    GC13123Lactacystin (Synthetic)
    CAS: 133343-34-7
    Purity: >95.00%

    Ein selektiver Inhibitor des 20S-Proteasoms.

  • GC13711 structure
    GC13711Gabexate mesylate
    CAS: 56974-61-9
    Purity: >98.00%

    A serine protease inhibitor

  • GC13718 structure
    GC13718MLN9708
    CAS: 1201902-80-8
    Purity: >98.00%

    A prodrug form of MLN2238

  • GC13789 structure
    GC13789AM 114
    CAS: 856849-35-9
    Purity: >98.50%
  • GC13865 structure
    GC13865PSI
    CAS: 158442-41-2
    Purity: >98%
  • GC15083 structure
    GC15083Celastrol
    CAS: 34157-83-0
    Purity: >99.50%

    Celastrol is a proteasome inhibitor with a potent and preferred inhibition of purified 20S proteasome with an IC 50 of 2.5 μM.

  • GC15089 structure
    GC15089Carfilzomib (PR-171)
    CAS: 868540-17-4
    Purity: >99.00%

    Carfilzomib (PR-171) is a next-generation tetrapeptide epoxyketone proteasome inhibitor (IC 50 =5nM).

  • GC15447 structure
    GC15447Oprozomib (ONX-0912)
    CAS: 935888-69-0
    Purity: >99.50%

    An orally available proteasome inhibitor

  • GC15517 structure
    GC15517MG-262
    CAS: 179324-22-2
    Purity: >98%

    A proteasome inhibitor with diverse biological activities