Adaptive Immunity

BMS 470539 (hydrochloride) is a highly selective and potent melanocortin-1 receptor (MC-1R) agonist. In cAMP accumulation assays, its EC 50 values for human and mouse MC1R are 16.8 and 11.6nM, respectively.

C12 Galactosylceramide is a bioactive sphingolipid.

C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide.

C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide.

C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.

The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2.

CCR4 antagonist is an antagonist of CC chemokine receptor 4 (CCR4) that inhibits human CCL22-derived [35S]GTPγS and [125I]CCL22 binding in vitro (IC50s = 19 and 70 nM, respectively).

Chk2-Inhibitor (Verbindung 1) ist ein potenter und selektiver Inhibitor der Checkpoint-Kinase 2 (Chk2) mit IC50-Werten von 13,5 nM und 220,4 nM fÜr Chk2 bzw. Chk1. Der Chk2-Inhibitor kann einen starken, von Ataxia telangiectasia mutated (ATM) abhÄngigen Chk2-vermittelten Strahlenschutzeffekt hervorrufen.

Cochlioquinone A, a bioactive compound isolated from D.

Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM).

Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP.

Cyclosporin B ist eine Gruppe unpolarer zyklischer Oligopeptide mit immunsuppressiver Wirkung.

Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid.

Feglymycin is a 13-amino acid peptide originally isolated from Streptomyces that has antibacterial and antiviral activities.

FTY720 ist ein Immunmodulator, der Sphingosin-1-Phosphat (S1P)-Rezeptoren herunterreguliert, die Aktivität des Sphingosin-Transporters ABCB1 und des Leukotrien-C4-Transporters ABCC1 erhöht und die Aktivität der zytosolischen Phospholipase A2 hemmt.

Galactosylcerebrosides are glycosphingolipids that contain a galactose attached to a ceramide acylated with a hydroxy or non-hydroxy fatty acid.

Galactosylcerebrosides are glycosphingolipids that contain a galactose attached to a ceramide acylated with a hydroxy or non-hydroxy fatty acid.

Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase.

Gemcitabine-13C,15N2 is intended for use as an internal standard for the quantification of gemcitabine by GC- or LC-MS.

Halofuginone is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D.

HDMAPP is a metabolite of the microbial dioxyxylulose-phosphate pathway, which is analogous to the isopentenyl pyrophosphate pathway in mammals.

Hydroxy Ebastine is an ebastine metabolite.

JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs).

Leucinostatin A (Antibiotikum P168) ist ein Nonapeptid, das insbesondere gegen Candida albicans und Cryptococcus neoformans eine bemerkenswerte AktivitÄt ausÜbt.