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Complement System

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The complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system. Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway.

Products Related to Complement System(69)

  • GC72326 structure
    GC72326Riliprubart
    CAS: 2756228-76-7
    Purity: >99.00%

    Riliprubart (SAR445088) ist ein humanisierter monoklonaler Antikörper gegen C1s, der aktivierte C1s im proximalen Teil des klassischen Komplementsystems hemmt.

  • GC72354 structure
    GC72354Lampalizumab
    CAS: 1278466-20-8
    Purity: >99.00%

    Lampalizumab (RG 7417) ist ein humanisierter monoklonaler Antikörper, der Komplementfaktor D im alternativen Komplementpfad zielt.

  • GC72391 structure
    GC72391Avdoralimab
    CAS: 2226393-85-5
    Purity: >95.00%

    Avdoralimab (IPH 5401) ist ein vollständig humaner monoklonaler IgGκ-Antikörper, der auf den Komplementrezeptor 1 (C5aR1) zielt, der seine Bindung an C5a verhindert.

  • GC72473 structure
    GC72473Crovalimab
    CAS: 1917321-26-6
    Purity: >98.00%

    Crovalimab (SKY59; RO7112689) ist ein neuartiger humanisierter Antikörper gegen C5 in pH-abhängiger Weise mit KDs von 15,2 nM und 16,8 μM bei pH 7,4 bzw. 5,8.

  • GC73106 structure
    GC73106Cemdisiran sodium
    Purity: >96.00%

    Cemdisiran sodium ist eine N-Acetylgalactosamin (GalNAc) konjugierte siRNA zur Erforschung komplementvermittelter Erkrankungen durch Unterdrückung der Leberproduktion von Komplement5 (C5)-Protein.

  • GC73413 structure
    GC73413ARC186 sodium
    Purity: >94.00%

    ARC186 sodium ist ein nicht jugiertes 40KDa PEG Aptamer mit einer Sequenz identisch mit 0 Avacincaptad Pegol ARC1905 Natrium.

  • GC74045 structure
    GC74045Zoracopan
    CAS: 2243483-63-6
    Purity: >99.00%

    Zoracopan ist ein selektiver Komplementfaktor D (CFD)-Hemmer.

  • GC74354 structure
    GC74354Pegcetacoplan acetate
    Purity: >98.00%

    Pegcetacoplan acetate ist ein pegyliertes C3-Inhibitor-Peptid.

  • GC74552 structure
    GC74552Gefurulimab
    CAS: 2456407-94-4
    Purity: >97.00%

    Gefurulimab (ALXN-1720) ist ein humaner bispezifischer Antikörper gegen Komplement C5 und Albumin, der C5 bindet und dessen Aktivierung blockiert.

  • GC74590 structure
    GC74590Pozelimab
    CAS: 2096328-94-6
    Purity: >99.00%

    Pozelimab (REGN3918) ist ein vollständig humaner IgG4 anti-C5 monoklonaler Antikörper.

  • GC79355 structure
    GC79355SAR-443809
    Purity: >97.00%

    SAR-443809 is a monoclonal antibody targeting complement factor Bb that inhibits the alternative complement pathway.

  • GC79356 structure
    GC79356Ascuprubart
    CAS: 3056020-15-3
    Purity: >97.50%

    Ascuprubart is an anti-human monoclonal antibody targeting Complement C5.

  • GC79357 structure
    GC79357ANX-M1 (Human IgG1)
    Purity: >99.00%

    ANX-M1 is a blood-brain barrier-permeable anti- C1q antibody.

  • GC79358 structure
    GC79358Lexucitug
    CAS: 3058391-51-5
    Purity: >98.00%

    Lexucitug (DCSZ-11) is a humanized monoclonal antibody targeting CD93.

  • GC79359 structure
    GC79359RPARPAR acetate
    Purity: >99.00%

    RPARPAR acetate is a CendR tumor-penetrating peptide.

  • GC79360 structure
    GC79360Pulchinenoside J
    CAS: 1476801-10-1
    Purity: >98%

    Pulchinenoside J is a lupane-type triterpenoid saponin and a complement system inhibitor that acts via the classical pathway.

  • GC79361 structure
    GC79361Vonaprument
    CAS: 3050549-24-8
    Purity: >98%

    Vonaprument (ANX-007) is an intravitreally injected C1q antibody fragment (with a molecular weight of approximately 48 kDa) and a human monoclonal antibody.

  • GC79362 structure
    GC79362Anti-CD55 Antibody
    Purity: >99.50%

    Anti-CD55 Antibody is an anti- CD55 antibody.

  • GC79418 structure
    GC79418NRPa-308
    CAS: 717863-53-1
    Purity: >98.50%

    NRPa-308 is a potent and orally active Neuropilin-1 (NRP-1) antagonist with an IC 50 of 42 μM for inhibiting VEGF-A 165 binding to NRP-1.

  • GC81483 structure
    GC81483AKIR001
    Purity: >99.00%

    AKIR001 is a high-affinity human IgG1 antibody targeting CD44v6.

  • GF10303 structure
    GF10303Lipoteichoic acid
    CAS: 56411-57-5

    Lipoteichoic acid is a teichoic acid predominantly located in the cell walls of Gram-positive bacteria, widely involved in stimulating immune responses and cellular signaling pathways.