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Dehydrogenase

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Dehydrogenases, belonging to the class of oxidoreductases which catalyze donor-acceptor reactions to transfer electron molecules from the oxidant to the reluctant, are a diverse group of enzymes that are able to transfer one or more hydrides (H-) from a substrate to an electron acceptor, such as nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+) or Riboflavin, through oxidation and reduction. Three commonly studied dehydrogenase enzymes include alcohol dehydrogenase (ADH) which catalyzes the reduction of acetylaldehyde to ethanol in plant cells, succinate dehydrogenase which oxidizes succinate to fumarate, and lactate dehydrogenase which catalyzes the reversible oxidation of lactate to pyruvate.

Products Related to Dehydrogenase(36)

  • GC16816 structure
    GC16816Galloflavin
    CAS: 568-80-9
    Purity: >98.00%

    Galloflavin ist ein starker Hemmer der Laktatdehydrogenase (LDH). Die berechneten Kis fÜr Pyruvat betragen 5,46 μM (LDH-A) und 15,06 μM (LDH-B). Galloflavin hemmt die Vermehrung von Krebszellen, indem es die Glykolyse und die ATP-Produktion blockiert.

  • GC16860 structure
    GC16860NCT-502
    CAS: 1542213-00-2
    Purity: >99.00%

    NCT-502 ist ein humaner Phosphoglyceratdehydrogenase (PHGDH)-Inhibitor, der fÜr PHGDH-abhÄngige Krebszellen zytotoxisch ist und die von Glukose abgeleitete Serinproduktion reduziert, mit einem IC50-Wert von 3,7 μM gegen PHGDH.

  • GC16951 structure
    GC16951Stiripentol
    CAS: 49763-96-4
    Purity: >99.50%

    Stiripentol (STP) ist ein Antikonvulsivum, das die durch CYP3A4 (nicht kompetitiv) und CYP2C19 (kompetitiv) vermittelte N-Demethylierung von CLB zu NCLB mit Ki von 1,59 ± 0,07 und 0,516 ± 0,065 μM und IC50 von 1,58 bzw. 3,29 μM hemmen kann .

  • GC17107 structure
    GC17107PluriSIn #1 (NSC 14613)
    CAS: 91396-88-2
    Purity: >99.50%

    A selective inhibitor of stearoyl-CoA desaturase

  • GC17293 structure
    GC17293PHGDH-inactive
    CAS: 1914971-16-6
    Purity: >99.50%

    PHGDH-inaktiv hat keine AktivitÄt gegen PHGDH und dient als negative Kontrolle von NCT-502 und NCT-503.

  • GC17467 structure
    GC17467Gimeracil
    CAS: 103766-25-2
    Purity: >99.50%

    A DYPD inhibitor

  • GC17914 structure
    GC17914Fomepizole
    CAS: 7554-65-6
    Purity: >99.50%

    Fomepizol (4-Methylpyrazol) ist ein starker Cytochrom P450 (CYP2E1)-Hemmer.

  • GC25039 structure
    GC25039AG-120 (racemic)
    CAS: 1448346-63-1
    Purity: >98%

    AG-120 (racemic), the racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity.

  • GC25389 structure
    GC25389Ethyl potassium malonate
    CAS: 6148-64-7
    Purity: >98%

    Ethyl potassium malonate (Potassium 3-ethoxy-3-oxopropanoate) is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation and serves as an intermediate for the preparation of ethyl tert-butyl malonate.

  • GC50508 structure
    GC50508PKUMDL WQ 2101
    CAS: 304481-72-9
    Purity: >98%

    Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)

  • GC50509 structure
    GC50509PKUMDL WQ 2201
    CAS: 592474-91-4
    Purity: >98%

    Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)

  • GC81900 structure
    GC81900CP61 acetate
    Purity: >98.50%

    CP61 acetate is a CtBP1 and CtBP2 inhibitor that binds to dimeric CtBP1 and allosterically inhibits NADH binding, disrupting the NADH -dependent dimerization of CtBP1 and CtBP2, inducing aberrant mitosis and micronucleus formation, thereby inhibiting cell proliferation and colony formation.