GLPBio

Ligand for E3 Ligase

The PROTAC molecule consists of a ligand, which binds an E3 ubiquitin ligase, connected by a linker to another ligand that binds the target protein.

The association between a protein and an E3 ligase, as induced by a PROTAC molecule, will lead to the transfer of ubiquitin and degradation of the targeted protein.

Products Related to Ligand for E3 Ligase(166)

  • GC80998 structure
    GC80998CRBN ligand-902
    CAS: 2913408-82-7
    Purity: >98.00%

    CRBN ligand-902 is a CRBN E3 ligase ligand that can be used for synthesis of PROTAC CDK2/4 Degrader-1 [1] .

  • GC80999 structure
    GC80999(R)-Desamino lenalidomide-5-Br
    CAS: 2243825-20-7
    Purity: >99.50%

    (R)-Desamino lenalidomide-5-Br is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81000 structure
    GC81000CRBN ligand-607
    CAS: 2925072-28-0
    Purity: >98%

    CRBN ligand-607 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81001 structure
    GC81001CRBN ligand-547
    CAS: 2446913-88-6
    Purity: >99.50%

    CRBN ligand-547 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81002 structure
    GC81002CRBN ligand-619
    CAS: 2229724-66-5
    Purity: >98.00%

    CRBN ligand-619 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81003 structure
    GC81003CRBN ligand-707
    CAS: 2925095-42-5
    Purity: >99.50%

    CRBN ligand-707 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81004 structure
    GC81004CRBN ligand-708
    CAS: 2925094-42-2
    Purity: >97.50%

    CRBN ligand-708 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81005 structure
    GC81005Desamino lenalidomide-6-Br-5-F
    CAS: 2438240-74-3
    Purity: >98.00%

    Desamino lenalidomide-6-Br-5-F is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81006 structure
    GC81006CRBN ligand-749
    CAS: 2760849-95-2
    Purity: >98.00%

    CRBN ligand-749 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81007 structure
    GC810075-Br-6-F-Desamino lenalidomide
    CAS: 2409005-96-3
    Purity: >98.00%

    5-Br-6-F-Desamino lenalidomide is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81008 structure
    GC81008CRBN ligand-733
    CAS: 2903425-10-3
    Purity: >98.00%

    CRBN ligand-733 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81009 structure
    GC81009CRBN ligand-896
    CAS: 2504234-93-7
    Purity: >98%

    CRBN ligand-896 (CRBN-1) is a E3 ligase ligand of PROTAC that can be used to synthesize PROTAC degraders targeting the epigenetic coactivator p300 [1] .

  • GC81010 structure
    GC81010CRBN ligand-774
    CAS: 2888604-15-5
    Purity: >98.00%

    CRBN ligand-774 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81011 structure
    GC81011Desamino lenalidomide-6-I
    CAS: 2757572-60-2
    Purity: >95.00%

    Desamino lenalidomide-6-I is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81012 structure
    GC81012Desamino lenalidomide-pinacolborane
    CAS: 2291363-98-7
    Purity: >98.00%

    Desamino lenalidomide-pinacolborane is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81013 structure
    GC81013CRBN ligand-838
    CAS: 2654822-43-0
    Purity: >98.00%

    CRBN ligand-838 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81014 structure
    GC81014CRBN ligand-734
    CAS: 2654830-24-5
    Purity: >98.00%

    CRBN ligand-734 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81015 structure
    GC81015(S,R,S)-AHPC-Me-NHBoc
    CAS: 1997302-16-5
    Purity: >99.50%

    (S,R,S)-AHPC-Me-NHBoc is an E3 ubiquitin ligase VHL ligand used to recruit the VHL protein.

  • GC81016 structure
    GC81016Thalidomide-O-amido-PEG2-Mal
    Purity: >97.50%

    Thalidomide-O-amido-PEG2-Mal is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein.

  • GC81017 structure
    GC81017DCAF1 ligand 2
    Purity: >99.50%

    DCAF1 ligand 2 (Tert-butyl (2-((2-(1-(4-chlorophenyl)cyclohexyl)-7-(piperazin-1-yl)quinazolin-4-yl)amino)ethyl)carbamate) is a ligand of the E3 connecting enzyme DCAF1.

  • GC81018 structure
    GC81018(S,R,S)-AHPC-Me-C8-NHS ester
    Purity: >99.50%

    The (S,R,S)-AHPC-Me-C8-NHS ester is an E3 ubiquitin ligase VHL ligand, used to recruit the VHL protein.

  • GC81019 structure
    GC81019BTR2000 TFA
    Purity: >98.50%

    BTR2000 TFA, a specifically KLHL20 ligand, is capable of binding to the KLHL20 Kelch domain with high affinity.