SA91-0178 |
Katalog-Nr.GC81697
One-Click Copy Product Info
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SA91-0178 is a METTL1 inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2244341-81-7
Sample solution is provided at 25 µL, 10mM.
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In Vivo, SA91-0178 (5-15 mg/kg, ip, once) demonstrates protective effects against multiple organ injury in cecal ligation and puncture (CLP)-induced septic C57BL/6 mice, while failing in Lyz2creMettl1fl/fl mice[1].
In Vitro, SA91-0178 inhibits LPS -induced TNF-α and IL-1β secretion in mouse bone marrow-derived macrophages (BMDMs) without cytotoxicity[1]. SA91-0178 attenuates LPS-induced m7G modification in RAW264.7 cells and human peripheral blood mononuclear cell (PBMC)-derived macrophages[1]. SA91-0178 reduces luciferase activity of wild-type SARM1 3'UTR reporter in shMETTL1-treated THP-1-derived macrophages[1].
References:
[1]. Hou C, et al. METTL1-mediated m7G methylation of Sarm1 mRNA promotes macrophage inflammatory responses and multiple organ injury. Sci Immunol. 2025 Sep 5;10(111):eadv4810.
| Cas No. | 2244341-81-7 | SDF | |
| Formula | C28H27N3O4 | M.Wt | 469.53 |
| Löslichkeit | DMSO: 100 mg/mL (212.98 mM; Need ultrasonic) | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.1298 mL | 10.6489 mL | 21.2979 mL |
| 5 mM | 426 μL | 2.1298 mL | 4.2596 mL |
| 10 mM | 213 μL | 1.0649 mL | 2.1298 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)