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| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $280.00 | In Stock | 1 | |
| 1mg | $133.00 | In Stock | 1 | |
| 5 mg | $296.00 | In Stock | 1 | |
| 10 mg | $444.00 | In Stock | 1 |
Sec61-IN-1 is an effective Sec61 inhibitor (Patent WO2020176863A1, compound A317).[1].
Sec61-IN-1 exhibits an EC50 of 2543nM after 48-hour treatment on NCI-H929 cells[1].
References:
[1]National Center for Biotechnology Information (2025). PubChem Patent Summary for WO-2020176863-A1, Thiazole derivatives as protein secretion inhibitors. Retrieved March 1, 2025 from https://pubchem.ncbi.nlm.nih.gov/patent/WO-2020176863-A1.
| Cell experiment [1]: | |
Cell lines | NCI-H929 cell |
Preparation Method | NCI-H929 cells were resuspended in RPMI 1640 media supplemented with 10% fetal bovine serum, 2mM Glutamine, and 1x Penicillin/Streptmycin and plated in 384-well tissue culture plates and treated with Sec61-IN-1 dilutions in DMSO/media. Plates were incubated at 37℃, 5% CO2 for 48 hours. After 48 hours, Celltiter-Glo was added to each well and luciferase signal was quantified for cell viability determination. |
Reaction Conditions | 48h |
Applications | EC50=2543nM |
References: | |