Other Signal Transduction

GATA4-NKX2-5-IN-1 (3i-1000) is a small-molecule compound inhibiting GATA4 and NKX2-5 transcriptional synergy with IC50 of 3 uM

Panx-1 mimetic inhibitory peptide, blocks pannexin-1 gap junctions

Hemmer von Endoplasmatischer-Reticulum-assoziierten Abbau (ERAD) und Proteintranslokation.

10Panx is a potent Panx1 channel inhibitor that targets the W74 to Y83 segment of the ECL1 of Panx1 protein.

Levetiracetam, ein Antiepileptikum, bindet das synaptische Vesikelprotein SV2A.

BLU-782 ist eine orale Präzisionstherapie, die speziell entwickelt wurde, um selektiv das mutierte ALK2 zu bekämpfen.

M2N12 ist ein potenter und hochselektiver Hemmer der 25C-Proteinphosphatase (Cdc25C) des Zellteilungszyklus mit einem IC50-Wert von 0,09 μM. M2N12 hat auch eine vielversprechende AktivitÄt gegen Cdc25A und Cdc25B mit IC50-Werten von 0,53 μM bzw. 1,39 μM. M2N12 hat Anti-Tumor-AktivitÄt und kann fÜr die Krebsforschung verwendet werden.

LP-935509 ist ein oral aktiver, potenter, selektiver, ATP-kompetitiver und gehirngängiger Inhibitor der Adaptorprotein-2-assoziierten Kinase 1 (AAK1) mit einer IC50 von 3,3 nM und einem Ki von 0,9 nM.

Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.

Compound 43 TAO kinase inhibitor is an ATP-competitive inhibitor of the thousand-and-one amino acid kinases TAOK1 and TAOK2 (IC50s = 11 and 15 nM, respectively).

Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.

D-myo-inositol-1,2,3,5,6-pentaphosphate (Ins(1,2,3,5,6)-P5) (sodium salt) is produced from Ins(1,2,3,4,5,6)P6 via a minor enzymatic phytate degradation pathway by K.

D-myo-Inositol-1,2,3,5-tetraphosphate (Ins(1,2,3,5)P4) is one of the many inositol phosphate isomers that could act as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1,2,4,5,6-pentaphosphate (sodium salt) (Ins(1,2,4,5,6)P5 (sodium salt)) is one of several different inositol oligophosphate isomers implicated in signal transduction.

Ins(1,2,4,5)P4 is one of the many inositol phosphate (InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals..

D-myo-Inositol-1,2,6-phosphate (Ins(1,2,6)-P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals.

The phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway plays critical roles in cell growth and proliferation making it an attractive target for anticancer agents.

The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals.

D-myo-Inositol-1,3,5-phosphate (Ins(1,3,5)P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals.

D-myo-Inositol-1,4-phosphate (Ins(1,4)P2) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1,5-phosphate (Ins(1,5)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate molecular family of second messengers that play critical roles in intracellular signaling.

D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate (InsP) molecular family of second messengers that play a critical role in the transmission of cellular signals.

D-myo-inositol-2,3,5,6-tetraphosphate (sodium salt) (Ins(2,3,5,6)-P4 (sodium salt)) is produced from Ins(1,2,3,5,6)P5 via a minor enzymatic phytate degradation pathway by K.