Tazofelone (Synonyms: LY 213829) |
| Katalog-Nr.GC64025 |
Tazofelon (LY 213829) ist ein Cyclooxygenase-II (COX-II)-Hemmer. Die Umwandlung von Tazofelon in Sulfoxid- und Chinol-Metaboliten wird hauptsÄchlich durch CYP3A vermittelt. Tazofelon kann zur Erforschung entzÜndlicher Darmerkrankungen eingesetzt werden.
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Cas No.: 107902-67-0
Sample solution is provided at 25 µL, 10mM.
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Tazofelone (LY 213829) is a cyclooxygenase-II (COX-II) inhibitor. Tazofelone transform into sulfoxide and quinol metabolites is primarily mediated by CYP3A. Tazofelone can be used for the research of inflammatory bowel disease[1][2].
[1]. Leopold Franz Goetze,et al. Cox- ii inhibitors for improving reproductive success in a female animal. Patent: WO2007129169 A2.
[2]. Surapaneni SS, et al. In vitro biotransformation and identification of human cytochrome P450 isozyme-dependent metabolism of tazofelone. Drug Metab Dispos. 1997 Dec;25(12):1383-8.
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