YM-53601 |
| Katalog-Nr.GC45174 |
YM-53601, ein Squalen-Synthase-Hemmer, senkt den Cholesterin- und Triglyceridspiegel im Plasma in vivo.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 182959-33-7
Sample solution is provided at 25 µL, 10mM.
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YM-53601 is a squalene synthase inhibitor (IC50s = 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively). It inhibits cholesterol biosynthesis in rats (ED50 = 32 mg/kg). YM-53601 dose-dependently reduces plasma triglyceride and non-HDL cholesterol levels in hamsters fed both normal and high-fat diets. It also reduces viral RNA, core and NS3 protein production, and secreted viral particles in Huh7.5.1-8 cells infected with the hepatitis C virus (HCV) strain JFH-1 without affecting cell viability at concentrations ranging from 0.5 to 1.5 μM. YM-53601 (1-10 μM) confers protection against cytotoxicity induced by the bacterial pore-forming toxin pneumolysin in HBE1 and normal human bronchial epithelial (NHBE) cells.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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