DNA-GAGA is a slow substrate for Ricin toxin A-chain (RTA). RTA depurinates a single adenylate on a GAGA stem-loop region of eukaryotic 28S RNA, making it a potent toxin [1].
References:
[1]. Tim K Amukele, et al. Ricin A-chain activity on stem-loop and unstructured DNA substrates. Biochemistry. 2005 Mar 22;44(11):4416-25.
References:
[1]. Tim K Amukele, et al. Ricin A-chain activity on stem-loop and unstructured DNA substrates. Biochemistry. 2005 Mar 22;44(11):4416-25.
















