DNA/RNA Oxidative Damage

8-Nitroguanine is a nitrative guanine derivative formed by oxidative damage to the guanine base in DNA by reactive nitrogen species (RNS) during inflammation and in vitro by reaction of DNA with peroxynitrite and other RNS reagents.

N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid and its prodrug form, sulfasalazine.

4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts.

8-Hydroxyguanine is produced by oxidative degradation of DNA by hydroxyl radical.

DNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis.

Gallotannin (Tannic acid) is a natural polyphenolic compound that has been found in various plants and has antioxidant, anti-inflammatory, anti-angiogenic, antiviral and anti-tumor biological activities. Gallotannin inhibits the activity of DNA polymerase α, β and κ with IC 50 values of 13, 130 and 30nM, respectively .

Nitrosobenzene is a spin trap that has been used in the study of oxidative DNA damage and nitroso-compound-induced respiratory burst in neutrophils.

An inhibitor of PARP1 and 2

A neuropeptide with diverse biological activities

An alkylresorcinol

5-Tricosylresorcinolthe is the first cyst lipid.

A flavonoid glycoside with antioxidant activity

A carbamate pesticide