GLPBio

DPP-4-IN-18

Catalog No.: GC79593Purity:>98%Synonyms: Sitagliptin impurity 3
COASDSData Sheet
DPP-4-IN-18 (Sitagliptin impurity 3) (Compound 4) impurity 3 is a potent, selective and orally active DPP-4 inhibitor with an IC50 of 27 nM.

Products are for research use only. Not for human use. We do not sell to patients.

DPP-4-IN-18
Cas No.: 486460-31-5
25mgIn Stock
$191.00
1
50mgIn Stock
$266.00
1
100mgIn Stock
$374.00
1
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Citations

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    Nature
    641, 529–536 (2025)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6734) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

DPP-4-IN-18 (Sitagliptin impurity 3) (Compound 4) impurity 3 is a potent, selective and orally active DPP-4 inhibitor with an IC50 of 27 nM. DPP-4-IN-18 can effectively prevent DPP-4 from degrading glucagon-like peptide 1 ( GLP-1 ), thereby increasing the level of active GLP-1. DPP-4-IN-18 can be used for the research of type 2 diabetes [1].

References:
[1]. Thornberry NA, et al. Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Curr Top Med Chem. 2007;7(6):557-68.

Chemical Properties

CAS No.
486460-31-5
Synonyms
Sitagliptin impurity 3
Molecular Formula
C16H16F5N5O
Molecular Weight
389.32
Storage
Store at -20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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