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Dipeptidyl Peptidase

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Dipeptidyl Peptidase (DPP) is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation,signal transduction and apoptosis. DPP is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPP are proline-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP plays a major role in glucose metabolism. DPP is responsible for the degradation of incretins such as GLP-1. Furthermore, DPP appears to work as a suppressor in the development of cancer and tumours. DPP plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.

Products Related to Dipeptidyl Peptidase(55)

  • GA22366 structure
    GA22366H-Glu(Tyr-OH)-OH
    CAS: 7432-23-7
    Purity: >98.00%

    H-Glu(Tyr-OH)-OH is a dipeptide composed of glutamic acid (Glu) and tyrosine (Tyr). Its chemical name is L-glutamyl-L-tyrosine, with the molecular formula C₁₄H₁₈N₂O₆ and a molecular weight of approximately 310.3. H-Glu(Tyr-OH)-OH is a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV) (IC₅₀ = 6.77mM) and may have potential for the treatment of type II diabetes.

  • GA22410 structure
    GA22410H-Gly-Arg-AMC
    CAS: 65147-19-5
    Purity: >98%

    H-Gly-Arg-AMC is a fluorogenic substrate for cathepsin C, with maximum excitation/emission wavelengths of 340-360/440-460nm.

  • GC10018 structure
    GC10018Talabostat mesylate
    CAS: 150080-09-4
    Purity: >99.00%

    Talabostat (PT100) is an orally active and non-selective inhibitor of dipeptidyl peptidase IV (DPP-IV) ( IC 50 < 4 nM; K i = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) ( IC 50 = 560 nM), inhibiting DPP 8/9 ( IC 50 = 4/11 nM; K i = 1.5/0.76 nM), prolyl endopeptidase (QPP) (IC50= 310 nM), DPP2, and other DASH family enzymes.

  • GC10091 structure
    GC10091Nateglinide
    CAS: 105816-04-4
    Purity: >99.50%

    Insulin secretagog agent

  • GC10171 structure
    GC10171Puromycin aminonucleoside
    CAS: 58-60-6
    Purity: >98.00%

    A glomerular epithelial cell toxin

  • GC10298 structure
    GC10298Sitagliptin phosphate monohydrate
    CAS: 654671-77-9
    Purity: >99.50%
  • GC12235 structure
    GC12235Sitagliptin (phosphate)
    CAS: 654671-78-0
    Purity: >98.00%

    DPP-4 inhibitor

  • GC12360 structure
    GC12360UAMC 00039 dihydrochloride
    CAS: 697797-51-6
    Purity: >99.50%

    dipeptidyl peptidase II (DPP-II) inhibitor

  • GC12895 structure
    GC12895Saxagliptin
    CAS: 361442-04-8
    Purity: >99.50%

    Saxagliptin is a highly potent dipeptidyl peptidase-4 (DPP-4) inhibitor that regulates blood glucose by selectively inhibiting the DPP-4 enzyme, thereby elevating levels of endogenous glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).

  • GC13949 structure
    GC13949Alogliptin Benzoate
    CAS: 850649-62-6
    Purity: >99.50%

    A DPP-4 inhibitor

  • GC14827 structure
    GC14827Linagliptin (BI-1356)
    CAS: 668270-12-0
    Purity: >99.50%

    A potent DPP-4 inhibitor

  • GC15130 structure
    GC15130Alogliptin (SYR-322)
    CAS: 850649-61-5
    Purity: >99.00%
  • GC15576 structure
    GC15576Teneligliptin hydrobromide
    CAS: 906093-29-6
    Purity: >99.50%

    A DPP-4 inhibitor

  • GC16613 structure
    GC16613Trelagliptin
    CAS: 865759-25-7
    Purity: >99.50%

    A DDP-4 inhibitor

  • GC16733 structure
    GC16733Vildagliptin (LAF-237)
    CAS: 274901-16-5
    Purity: >98.00%

    A DPP-4 inhibitor

  • GC17012 structure
    GC17012MK3102
    CAS: 1226781-44-7
    Purity: >99.00%

    MK3102 (Omarigliptin) is a novel once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor (IC50: 2.2 nM) developed for the treatment of type 2 diabetes.

  • GC17479 structure
    GC17479Trelagliptin succinate
    CAS: 1029877-94-8
    Purity: >99.50%

    A DDP-4 inhibitor

  • GC19052 structure
    GC19052AZD7986
    CAS: 1802148-05-5
    Purity: >99.00%

    AZD7986 (AZD7986) is an oral dipeptidyl peptidase 1 (DPP1) inhibitor with pIC50s of 6.85, 7.6, 7.7, 7.8, and 7.8 in human, mouse, rat, dog and rabbit, respectively.

  • GC19120 structure
    GC19120DBPR108
    CAS: 1186426-66-3
    Purity: >99.50%

    DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9.

  • GC30877 structure
    GC30877DPP-IV-IN-2
    CAS: 136259-18-2
    Purity: >98.00%

    DPP-IV-IN-2 is an inhibitor of both dipeptidyl peptidase IV (DPIV) and DP8/9 with IC50s of 0.1 and 0.95 μM, respectively.

  • GC31317 structure
    GC31317Sitagliptin (MK0431)
    CAS: 486460-32-6
    Purity: >99.50%

    Sitagliptin (MK0431) is an oral and highly selective Dipeptidyl peptidase-4 (DPP-4) inhibitor with an IC 50 of 18nM.

  • GC31333 structure
    GC31333Teneligliptin (MP-513)
    CAS: 760937-92-6
    Purity: >99.50%

    Teneligliptin (MP-513) (MP-513) is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor.

  • GC31341 structure
    GC31341Anagliptin (SK-0403)
    CAS: 739366-20-2
    Purity: >98%

    Anagliptin (SK-0403) (SK-0403) is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC50s of 68 nM and 60 nM, respectively.

  • GC31414 structure
    GC31414Diprotin A TFA (Ile-Pro-Pro (TFA))
    CAS: 209248-71-5
    Purity: >98.50%

    Diprotin A TFA (Ile-Pro-Pro (TFA)) (Ile-Pro-Ile TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).