GLPBio

DS69910557

Catalog No.: GC73163Purity:>99.00%
COASDSData Sheet
DS69910557 is a potent, selective and orally activehuman paratroid hormone receptor 1 (hPTHR1) antagonist.

Products are for research use only. Not for human use. We do not sell to patients.

DS69910557
10mM (in 1mL DMSO)In Stock
$823.00
1
1 mgIn Stock
$278.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

DS69910557 is a potent, selective and orally activehuman paratroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC50 value of 0.08 μM. DS69910557 can be used for the research of perparatroidism, percalcemia of malignancy and osteoporosis.

DS69910557 (compound 19e) has highly potent antagonistic activity for PTHR1 with an IC50 value of 0.08 μM[1].DS69910557 (3 μM) exhibits excellent selectivity against human ether-a-go-go-related-gene (hERG) channel[1].

DS69910557 (compound 19e) (p.o.; 5mg/kg) has potency to decrease the plasma calcium concentration in rats in vivo[1].

References:
[1]. Yoshikazu Arai, et al. Lead optimization of pyrido[2,3-d][1]benzazepin-6-one derivatives leading to the discovery of a potent, selective, and orally available human paratroid hormone receptor 1 (hPTHR1) antagonist (DS69910557). Bioorg Med Chem. 2022 Jun 15;64:116763.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Molecular Formula
C32H33Cl2FN4O3
Molecular Weight
611.53
Solubility
DMSO : 100 mg/mL (163.52 mM; Need ultrasonic)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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