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Duoperone

Catalog No.GC31031

Duoperone is a neuroleptic agent and also a antiemetic agent in animal models.

Products are for research use only. Not for human use. We do not sell to patients.

Duoperone Chemical Structure

Cas No.: 62030-88-0

Size Price Stock Qty
1mg
$276.00
In stock
5mg
$552.00
In stock
10mg
$937.00
In stock
20mg
$1,655.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Duoperone is a neuroleptic agent and also a antiemetic agent in animal models.

Duoperone blocks d-amphetamine lethality in mice under aggregated conditions when the pretreatment interval is between one hour and seven days. ABR-6646 produces catalepsy in rats. The onset of this effect is delayed and the duration is prolonged when compared with that of chlorpromazine. Apomorphine-induced pivoting in mice with unilateral lesions of the caudate nucleus is suppressed by ARR-6646[1].

[1]. Johnson DN, et al. AHR-6646: a new, long-acting neuroleptic. Prog Neuropsychopharmacol. 1979;3(5-6):513-20.

Chemical Properties

Cas No. 62030-88-0 SDF
Canonical SMILES O=C(C1=CC=C(F)C=C1)C2CCN(CCCN3C4=C(C=CC=C4)SC5=CC=C(C(F)(F)F)C=C35)CC2
Formula C28H26F4N2OS M.Wt 514.58
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.9433 mL 9.7167 mL 19.4333 mL
5 mM 0.3887 mL 1.9433 mL 3.8867 mL
10 mM 0.1943 mL 0.9717 mL 1.9433 mL
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**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for Duoperone

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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