GLPBio

Bromodomain

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Bromodomains are a family of evolutionarily conserved protein modules of approximately 110 amino acids that have been found in chromatin-associated proteins as well as nuclear histone acetyltransferases (HATs). Besides its role in chromatin remodeling, recent studies have identified that bromodomains, as acetyl-lysine binding domains, are able to recognize and bind ε–N-acetylated lysine residues in histone and non-histone proteins. The nuclear magnetic resonance (NMR) spectroscopic analysis reveals that the chemical structure of bromodomains, consisting of four left-handed α-helices (including αZ, αA, αB and αC) connected by two loops (ZA and BC loops), forms a deep hydrophobic cavity serving as the acetyl-lysine recognition site.

Products Related to Bromodomain(44)

  • GC10382 structure
    GC10382CPI-637
    CAS: 1884712-47-3
    Purity: >99.50%

    CBP/EP300 bromodomain inhibitor

  • GC10402 structure
    GC10402Bromosporine
    CAS: 1619994-69-2
    Purity: >99.50%

    A non-specific bromodomain inhibitor

  • GC10524 structure
    GC10524GSK 525768A
    CAS: 1260530-25-3
    Purity: >99.00%
  • GC10727 structure
    GC10727Ischemin sodium salt
    Purity: >98%

    CBP bromodomain inhibitor

  • GC10979 structure
    GC10979PFI 4
    CAS: 900305-37-5
    Purity: >98.00%

    Potent and selective BRPF1 Bromodomain inhibitor

  • GC12440 structure
    GC12440GSK 5959
    CAS: 901245-65-6
    Purity: >98.00%

    BRPF1 bromodomain inhibitor

  • GC12588 structure
    GC12588I-BRD9
    CAS: 1714146-59-4
    Purity: >99.50%

    BRD9 inhibitor

  • GC13014 structure
    GC13014AZD 5153
    CAS: 1869912-39-9
    Purity: >98%

    AZD 5153 is a bivalent BET/BRD4 bromodomain inhibitor with an IC₅₀ of 5nM for BRD4, which simultaneously binds to both bromodomains of BRD4, significantly modulates MYC, E2F, and mTOR transcriptional programs, and inhibits the expression of NSD3 target genes.

  • GC13025 structure
    GC13025GSK6853
    CAS: 1910124-24-1
    Purity: >99.00%

    BRPF1 inhibitor

  • GC13187 structure
    GC13187I-BET 151 hydrochloride
    Purity: >98%

    BET bromodomain inhibitor

  • GC13822 structure
    GC13822(-)-JQ1
    CAS: 1268524-71-5
    Purity: >99.50%

    A selective inhibitor of BET bromodomains

  • GC14168 structure
    GC14168UMB-32
    CAS: 1635437-39-6
    Purity: >98%

    inhibitor of the BET bromodomain BRD4 and the bromodomain-containing transcription factor TAF1 and TAF1L

  • GC14361 structure
    GC14361PFI 3
    CAS: 1819363-80-8
    Purity: >98.00%

    inhibitor of polybromo 1 and SMARCA4

  • GC14655 structure
    GC14655OXF BD 02
    CAS: 1429129-68-9
    Purity: >98%

    Selective inhibitor of the first bromodomain of BRD4

  • GC15152 structure
    GC15152PF-CBP1
    CAS: 1962928-21-7
    Purity: >98%

    CBP/p300 bromodomain inhibitor

  • GC15175 structure
    GC15175BAZ2-ICR
    CAS: 1665195-94-7
    Purity: >98.50%

    Selective BAZ2 bromodomain inhibitor

  • GC15375 structure
    GC15375PFI-1 (PF-6405761)
    CAS: 1403764-72-6
    Purity: >99.50%

    A BET bromodomain inhibitor

  • GC15789 structure
    GC15789GSK2801
    CAS: 1619994-68-1
    Purity: >99.50%

    inhibitor of BAZ2A and BAZ2B bromodomains

  • GC16299 structure
    GC16299BET bromodomain inhibitor
    CAS: 1380087-89-7
    Purity: >99.50%

    Potent and selective inhibitor for BRD4

  • GC16531 structure
    GC16531Bromodomain Inhibitor, (+)-JQ1
    CAS: 1268524-70-4
    Purity: >99.50%

    A selective inhibitor of BET bromodomains

  • GC16611 structure
    GC16611GW841819X
    Purity: >98%

    BET bromodomain inhibitor

  • GC16726 structure
    GC16726BI-7273
    CAS: 1883429-21-7
    Purity: >99.50%

    BRD9 bromodomain inhibitor

  • GC16763 structure
    GC16763NI-57
    CAS: 1883548-89-7
    Purity: >99.50%

    bromodomains of BRPF proteins inhibitor

  • GC16794 structure
    GC16794UNC1215
    CAS: 1415800-43-9
    Purity: >98.00%

    Potent L3MBTL3 domain inhibitor