Bromodomain

Bromodomains are a family of evolutionarily conserved protein modules of approximately 110 amino acids that have been found in chromatin-associated proteins as well as nuclear histone acetyltransferases (HATs). Besides its role in chromatin remodeling, recent studies have identified that bromodomains, as acetyl-lysine binding domains, are able to recognize and bind ε–N-acetylated lysine residues in histone and non-histone proteins. The nuclear magnetic resonance (NMR) spectroscopic analysis reveals that the chemical structure of bromodomains, consisting of four left-handed α-helices (including αZ, αA, αB and αC) connected by two loops (ZA and BC loops), forms a deep hydrophobic cavity serving as the acetyl-lysine recognition site.

Products Related to Bromodomain(44)

GC16817 BI-9564
CAS: 1883429-22-8
Purity: >99.50%
BRD9/7 specific inhibitor
GC17482 OF-1
CAS: 919973-83-4
Purity: >98.00%
BRPF1B and BRPF2 bromodomain inhibitor
GC17973 OTX-015
CAS: 202590-98-5
Purity: >99.50%
OTX-015 inhibits the binding of BRD2, BRD3, and BRD4 to acetylated histone 4 in a concentration-dependent manner, with IC 50 values from 92-112nM.
GC18750 NEO2734
CAS: 2081072-29-7
Purity: >99.50%
An orally active dual p300/CBP and BET bromodomain selective inhibitor
GC43320 CPI-268456
CAS: 1380087-86-4
Purity: >98.00%
CPI-268456 (compound 141) is a potent BRD4 inhibitor with an IC50 of <0.5 μM.
GC43889 I-CBP112 (hydrochloride)
CAS: 2147701-33-3
Purity: >90.00%
cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators that modulate DNA replication, DNA repair, cell growth, transformation, and development.
GC45503 L-Moses (hydrochloride)
Purity: >98.00%
GC45640 TP-238 (hydrochloride)
CAS: 2415263-05-5
Purity: >99.00%
A neuropeptide with diverse biological activities
GC46675 4-Phenyl-2-pyrrolidinone
CAS: 1198-97-6
Purity: >98.00%
A precursor and synthetic intermediate
GC48408 TW9
CAS: 2614417-90-0
Purity: >98.00%
A dual inhibitor of BRD4 and HDAC1
GC49029 CAY17c
CAS: 2414373-11-6
Purity: >98.00%
An inhibitor of BRD4 and class I and class IIb HDACs
GC50070 I-BET 151 dihydrochloride
CAS: 1883545-47-8
Purity: >98%
BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes
GC60182 GSK046
CAS: 2474876-09-8
Purity: >98.00%
GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively.
GC14199 RVX-208
CAS: 1044870-39-4
Purity: >99.00%
RVX-208 (RVX-208) is an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. The IC50s are 87 μM and 0.51 μM for BD1 and BD2, respectively.
GC15747 I-BET151 (GSK1210151A)
CAS: 1300031-49-5
Purity: >99.50%
I-BET151 (GSK1210151A) (GSK1210151A) is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively.
GC17073 I-BET-762
CAS: 1260907-17-2
Purity: >99.00%
I-BET-762 (I-BET762; GSK525762) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.
GC18096 UNC669
CAS: 1314241-44-5
Purity: >98.50%
L3MBTL antagonist,potent and selective
GC13148 MS436
CAS: 1395084-25-9
Purity: >99.00%
BRD4 inhibitor
GC14063 GSK1324726A
CAS: 1300031-52-0
Purity: >98.00%
BET proteins inhibitor
GC14699 CPI-203
CAS: 1446144-04-2
Purity: >99.00%
BET bromodomain inhibitor

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC16817	BI-9564	1883429-22-8	>99.50%
GC16817	BRD9/7 specific inhibitor
GC17482	OF-1	919973-83-4	>98.00%
GC17482	BRPF1B and BRPF2 bromodomain inhibitor
GC17973	OTX-015	202590-98-5	>99.50%
GC17973	OTX-015 inhibits the binding of BRD2, BRD3, and BRD4 to acetylated histone 4 in a concentration-dependent manner, with IC 50 values from 92-112nM.
GC18750	NEO2734	2081072-29-7	>99.50%
GC18750	An orally active dual p300/CBP and BET bromodomain selective inhibitor
GC43320	CPI-268456	1380087-86-4	>98.00%
GC43320	CPI-268456 (compound 141) is a potent BRD4 inhibitor with an IC50 of <0.5 μM.
GC43889	I-CBP112 (hydrochloride)	2147701-33-3	>90.00%
GC43889	cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators that modulate DNA replication, DNA repair, cell growth, transformation, and development.
GC45503	L-Moses (hydrochloride)	-	>98.00%
GC45503
GC45640	TP-238 (hydrochloride)	2415263-05-5	>99.00%
GC45640	A neuropeptide with diverse biological activities
GC46675	4-Phenyl-2-pyrrolidinone	1198-97-6	>98.00%
GC46675	A precursor and synthetic intermediate
GC48408	TW9	2614417-90-0	>98.00%
GC48408	A dual inhibitor of BRD4 and HDAC1
GC49029	CAY17c	2414373-11-6	>98.00%
GC49029	An inhibitor of BRD4 and class I and class IIb HDACs
GC50070	I-BET 151 dihydrochloride	1883545-47-8	>98%
GC50070	BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes
GC60182	GSK046	2474876-09-8	>98.00%
GC60182	GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively.
GC14199	RVX-208	1044870-39-4	>99.00%
GC14199	RVX-208 (RVX-208) is an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. The IC50s are 87 μM and 0.51 μM for BD1 and BD2, respectively.
GC15747	I-BET151 (GSK1210151A)	1300031-49-5	>99.50%
GC15747	I-BET151 (GSK1210151A) (GSK1210151A) is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively.
GC17073	I-BET-762	1260907-17-2	>99.00%
GC17073	I-BET-762 (I-BET762; GSK525762) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.
GC18096	UNC669	1314241-44-5	>98.50%
GC18096	L3MBTL antagonist,potent and selective
GC13148	MS436	1395084-25-9	>99.00%
GC13148	BRD4 inhibitor
GC14063	GSK1324726A	1300031-52-0	>98.00%
GC14063	BET proteins inhibitor
GC14699	CPI-203	1446144-04-2	>99.00%
GC14699	BET bromodomain inhibitor