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FAS

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Fatty Acid Synthase (FAS) is a multifunctional homodimeric enzyme protein, and it is the major enzyme required for the anabolic conversion of dietary carbohydrates to fatty acids. Fatty acid synthase catalyzes the conversion of acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.

Human fatty acid synthase is a large homodimeric multifunctional enzyme that synthesizes palmitic acid. The unique carboxyl terminal thioesterase domain of fatty acid synthase hydrolyzes the growing fatty acid chain and plays a critical role in regulating the chain length of fatty acid released. Also, the up-regulation of human fatty acid synthase in a variety of cancer makes the thioesterase a candidate target for therapeutic treatment.

Fatty acid synthase of animal tissues is a complex multifunctional enzyme consisting of two identical monomers.

Products Related to FAS(24)

  • GC14025 structure
    GC14025Cerulenin
    CAS: 17397-89-6
    Purity: >98.00%

    fatty acid synthase (FAS) inhibitor

  • GC14316 structure
    GC14316ML-356
    CAS: 1808260-45-8
    Purity: >98%

    thioesterase domain of fatty acid synthase (FAS-TE) inhibitor

  • GC15091 structure
    GC15091UCM05
    CAS: 1094451-90-7
    Purity: >95.00%

    fatty acid synthase inhibitor

  • GC15572 structure
    GC15572(+)-trans-C75
    CAS: 1234694-20-2
    Purity: >99.50%

    enantiomer of C75, a fatty acid synthase (FAS) inhibitor

  • GC16184 structure
    GC16184(-)-trans-C75
    CAS: 1234694-22-4
    Purity: ≥97.00%

    enantiomer of C75, a FAS inhibitor

  • GC17318 structure
    GC17318Orlistat
    CAS: 96829-58-2
    Purity: >98.00%

    Orlistat is an irreversible inhibitor of lipases in the pancreas and stomach.

  • GC18121 structure
    GC18121Fatostatin A hydrobromide
    CAS: 298197-04-3
    Purity: >99.50%

    Fatostatin A hydrobromide is a compound that specifically inhibits the activity of sterol regulatory element-binding proteins (SREBPs), effectively suppressing the activation of SREBP-1 and SREBP-2.

  • GC31323 structure
    GC31323FGH10019
    CAS: 1046045-61-7
    Purity: >99.00%

    FGH10019 is a novel sterol regulatory element-binding protein (SREBP) inhibitor with IC50 of 1 μM.

  • GC31406 structure
    GC31406FAS-IN-1
    CAS: 1375105-96-6
    Purity: >99.00%

    FAS-IN-1 is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29).

  • GC33346 structure
    GC33346HS80
    CAS: 2138838-57-8
    Purity: >98%

    HS-80 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-80 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 7.13 μM.

  • GC33374 structure
    GC33374HS79
    CAS: 2138838-56-7
    Purity: >98%

    HS-79 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-79 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 1.57 μM.

  • GC33398 structure
    GC33398FASN inhibitor 1
    CAS: 2097262-60-5
    Purity: >98.00%

    FASN inhibitor 1 is a fatty acid synthase (FASN) inhibitor extracted from patent US20170119786A1, compound 242A.

  • GC34065 structure
    GC34065C75
    CAS: 218137-86-1
    Purity: >99.50%

    C75 is a specific inhibitor of fatty acid synthase (FASN/FAS) with moderate inhibitory activity, showing an IC50 value of 15.53 μM.

  • GC34311 structure
    GC34311FAS-IN-1 Tosylate
    Purity: >98%
  • GC34584 structure
    GC34584FASN-IN-1
    CAS: 1808260-84-5
    Purity: >99.50%

    FASN-IN-1 is a fatty acid synthase (FASN) inhibitor extracted from patent WO2015134790A1, compound 56.

  • GC36030 structure
    GC36030FASN-IN-2
    CAS: 1399177-37-7
    Purity: >98.00%

    FASN-IN-2 (TVB-2640) is an orally active and potent Fatty Acid Synthase (FASN) inhibitor with an IC50 of 0.052 μM and an EC50 of 0.072 μM.

  • GC36031 structure
    GC36031Fatostatin
    CAS: 125256-00-0
    Purity: >98.00%

    Fatostatin (125B11) is a specific inhibitor of sterol regulatory element-binding proteins (SREBP) activation, inhibiting the activation of both SREBP-1 and SREBP-2.

  • GC36736 structure
    GC36736Nicodicosapent
    CAS: 1269181-69-2
    Purity: >98.00%

    Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.

  • GC38221 structure
    GC38221Desoxyrhaponticin
    CAS: 30197-14-9
    Purity: >98.00%

    Desoxyrhaponticin, a stilbene glycoside from rhubarb, is a potent BACE1 inhibitor with an IC 50 value of 1.213μM.

  • GC38535 structure
    GC38535Dihydrocurcumin
    CAS: 76474-56-1
    Purity: >99.50%
  • GC38710 structure
    GC38710TVB-3166
    CAS: 1533438-83-3
    Purity: >99.50%

    TVB-3166 is an orally active fatty acid synthase (FASN) inhibitor (IC 50 =42nM). TVB-3166 inhibits cellular palmitate synthesis (IC 50 =81nM).

  • GC38839 structure
    GC38839Pseudoprotodioscin
    CAS: 102115-79-7
    Purity: >98.00%

    Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.

  • GN10392 structure
    GN10392Praeruptorin B
    CAS: 81740-07-0
    Purity: >99.50%
  • GN10632 structure
    GN10632Betulin
    CAS: 473-98-3
    Purity: >98.00%