GLPBio

FLY26

Catalog No.: GC83039Purity:>99.50%
COASDSData Sheet
FLY26 is a selective partial GluN2B antagonist with an IC50 value of 0.64 μM.

Products are for research use only. Not for human use. We do not sell to patients.

FLY26
10mM (in 1mL DMSO)In Stock
$173.00
1
5mgIn Stock
$158.00
1
10mgIn Stock
$252.00
1
25mgIn Stock
$461.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

FLY26 is a selective partial GluN2B antagonist with an IC50 value of 0.64 μM. FLY26 partially inhibits the GluN2B subunit of NMDA receptors, reduces calcium ion influx and reactive oxygen species (ROS) production and activates the BDNF/TrkB/CREB neuroprotective signaling pathway to alleviate neuronal excitotoxicity and mitochondrial dysfunction. FLY26 is promising for research of neurological deficits caused by cerebral ischemia-reperfusion injury [1].

References:
[1]. Fan Y, et al. A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats. Bioorg Chem. 2025 Apr 30;161:108547.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

Molecular Formula
C22H23N5O3
Molecular Weight
405.45
Solubility
DMSO: 125 mg/mL (308.30 mM; Need ultrasonic)
Storage
Store at 4°C, sealed storage, away from moisture
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

Reviews

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