Corynoxine: Autophagy Inducer with Reduced Locomotor Activity in Mice
Corynoxine is an enantiomer of Corynoxine B; induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.IC50 value: Target: Autophagy inducerIn vivo, Cory promotes the formation of autophagosomes in the fat bodies of Drosophila. By inducing autophagy, Cory promotes the clearance of wild-type and A53T α-syn in inducible PC12 cells. Interestingly, different from its enantiomer Cory B, Cory induces autophagy through the Akt/mTOR pathway as evidenced by the reduction in the levels of phospho-Akt, phospho-mTOR and phospho-p70 S6 Kinase [1]. Corynoxine significantly decreased locomotor activity after oral administration to mice [2].
References for Corynoxine:
[1]. Chen LL, et al. Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via the Akt/mTOR pathway. J Neuroimmune Pharmacol. 2014 Jun;9(3):380-7.
[2]. Sakakibara I, et al. Effect on the locomotion of indole alkaloids from the hooks of Uncaria plants. Phytomedicine. 1999 Jul;6(3):163-8.