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E3 ligase Ligand 17

Catalog No.GC35931

E3 ligase Ligand 17 est un conjugué ligand-linker E3 ligase synthétisé qui incorpore le ligand cereblon À base de pomalidomide et un linker PEG utilisé dans la technologie PROTAC.

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E3 ligase Ligand 17 Chemical Structure

Cas No.: 1957235-66-3

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

E3 ligase Ligand 17 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.

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