OD 36 hydrochloride |
| Catalog No.GC50517 |
Le chlorhydrate d'OD 36 est un inhibiteur de RIPK2 avec une IC50 de 5,3 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1638644-62-8
Sample solution is provided at 25 µL, 10mM.
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Potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC50 = 5.3 nM). Displays similar % inhibition against ALK-2 and SIK2 at 100 nM. Downregulates expression of a panel of RIPK2-dependent genes. Inhibits recruitment of inflammatory cells in a mouse MDP-induced peritonitis model.
Tigno-Aranjuez et al (2014) In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J.Biol.Chem. 289 29651 PMID:25213858 |SÁnchez-Duffhues et al (2019) Development of macrocycle kinase inhibitors for ALK2 using Fibrodysplasia ossificans progressiva-derived endothelial cells. JBMRPlus 3 e10230 PMID:31768489
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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